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Transcriptome profiles of sturgeon lateral line electroreceptor and mechanoreceptor during regeneration.
Wang, Jian; Lu, Chengcheng; Zhao, Yifan; Tang, Zhijiao; Song, Jiakun; Fan, Chunxin.
Afiliación
  • Wang J; International Joint Center for Marine Biological Sciences Research, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China.
  • Lu C; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China.
  • Zhao Y; International Joint Center for Marine Biological Sciences Research, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China.
  • Tang Z; Institute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai, China.
  • Song J; International Joint Center for Marine Biological Sciences Research, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China.
  • Fan C; Institute for Marine Biosystem and Neuroscience, International Center for Marine Studies, Shanghai Ocean University, Shanghai, China.
BMC Genomics ; 21(1): 875, 2020 Dec 07.
Article en En | MEDLINE | ID: mdl-33287707
BACKGROUND: The electrosensory ampullary organs (AOs) and mechanosensory neuromasts (NMs) found in sturgeon and some other non-neopterygian fish or amphibians are both originated from lateral line placodes. However, these two sensory organs have characteristic morphological and physiological differences. The molecular mechanisms for the specification of AOs and NMs are not clearly understood. RESULTS: We sequenced the transcriptome for neomycin treated sturgeon AOs and NMs in the early regeneration stages, and de novo assembled a sturgeon transcriptome. By comparing the gene expression differences among untreated AOs, NMs and general epithelia (EPs), we located some specific genes for these two sensory organs. In sturgeon lateral line, the voltage-gated calcium channels and voltage-gated potassium channels were predominant calcium and potassium channel subtypes, respectively. And by correlating gene expression with the regeneration process, we predicated several candidate key transcriptional regulation related genes might be involved in AOs and NMs regeneration. CONCLUSIONS: Genes with specific expression in the two lateral line sensory organs suggests their important roles in mechanoreceptor and electroreceptor formation. The candidate transcriptional regulation related genes may be important for mechano- and electro- receptor specification, in a "dosage-related" manner. These results suggested the molecular basis for specification of these two sensory organs in sturgeon.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema de la Línea Lateral Límite: Animals Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema de la Línea Lateral Límite: Animals Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido