Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors.

Lito, Silvin; Sidibe, Adama; Ilmjarv, Sten; Burda, Patricie; Baumgartner, Matthias; Wehrle-Haller, Bernhard; Krause, Karl-Heinz; Marteyn, Antoine

Lito, Silvin; Sidibe, Adama; Ilmjarv, Sten; Burda, Patricie; Baumgartner, Matthias; Wehrle-Haller, Bernhard; Krause, Karl-Heinz; Marteyn, Antoine.

Afiliación

Lito S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland.
Sidibe A; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland.
Ilmjarv S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland.
Burda P; Division of Metabolism and Children's Research Center, University Children's Hospital, CH-8032 Zürich, Switzerland.
Baumgartner M; Division of Metabolism and Children's Research Center, University Children's Hospital, CH-8032 Zürich, Switzerland.
Wehrle-Haller B; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland.
Krause KH; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland.
Marteyn A; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland.

Cells ; 9(12)2020 12 03.

Article en En | MEDLINE | ID: mdl-33287330

Asunto(s)

Movimiento Celular/genética; Células Madre Pluripotentes Inducidas/metabolismo; Mucopolisacaridosis I/metabolismo; Neuronas/metabolismo; Diferenciación Celular/genética; Células Cultivadas; Expresión Génica/genética; Glicosaminoglicanos/genética; Glicosaminoglicanos/metabolismo; Humanos; Iduronidasa/genética; Iduronidasa/metabolismo; Lisosomas/genética; Lisosomas/metabolismo; Mucopolisacaridosis I/genética; Mutación/genética; Fenotipo

Palabras clave

disease modelling; induced pluripotent stem cells; mucopolysaccharidosis I; neural migration; neurite outgrowth; neuronal differentiation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Movimiento Celular / Mucopolisacaridosis I / Células Madre Pluripotentes Inducidas / Neuronas Límite: Humans Idioma: En Revista: Cells Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Suiza

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