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Milk Fat Globule Membrane as a Modulator of Infant Metabolism and Gut Microbiota: A Formula Supplement Narrowing the Metabolic Differences between Breastfed and Formula-Fed Infants.
Lee, Hanna; Slupsky, Carolyn M; Heckmann, Anne B; Christensen, Britt; Peng, Yongmei; Li, Xiaonan; Hernell, Olle; Lönnerdal, Bo; Li, Zailing.
Afiliación
  • Lee H; Department of Food Science and Technology, University of California-Davis, Davis, CA, 95616, USA.
  • Slupsky CM; Department of Food Science and Technology, University of California-Davis, Davis, CA, 95616, USA.
  • Heckmann AB; Department of Nutrition, University of California-Davis, Davis, CA, 95616, USA.
  • Christensen B; Arla Foods Ingredients, 8260 Viby J, Aarhus N, Denmark.
  • Peng Y; Arla Foods amba, Arla Innovation Center, Skejby, Aarhus N, Denmark.
  • Li X; Department of Child Health Care, Children's Hospital of Fudan University, No 339 Wanyuan Road, Shanghai, 200032, China.
  • Hernell O; Department of Child Health Care, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, Jiangsu Province, China.
  • Lönnerdal B; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, 901 87, Sweden.
  • Li Z; Department of Nutrition, University of California-Davis, Davis, CA, 95616, USA.
Mol Nutr Food Res ; 65(3): e2000603, 2021 02.
Article en En | MEDLINE | ID: mdl-33285021
SCOPE: Milk fat globule membrane (MFGM) is an important component of milk that has previously been removed in the manufacture of infant formulas, but has recently gained attention owing to its potential to improve immunological, cognitive, and metabolic health. The goal of this study is to determine whether supplementing MFGM in infant formula would drive desirable changes in metabolism and gut microbiota to elicit benefits observed in prior studies. METHODS AND RESULTS: The serum metabolome and fecal microbiota are analyzed using 1 H NMR spectroscopy and 16S rRNA gene sequencing respectively in a cohort of Chinese infants given a standard formula or a formula supplemented with an MFGM-enriched whey protein fraction. Supplementing MFGM suppressed protein degradation pathways and the levels of insulinogenic amino acids that are typically enhanced in formula-fed infants while facilitating fatty acid oxidation and ketogenesis, a feature that may favor brain development. MFGM supplementation did not induce significant compositional changes in the fecal microbiota but suppressed microbial diversity and altered microbiota-associated metabolites. CONCLUSION: Supplementing MFGM in a formula reduced some metabolic gaps between formula-fed and breastfed infants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lactancia Materna / Glucolípidos / Glicoproteínas / Fórmulas Infantiles / Microbioma Gastrointestinal Tipo de estudio: Clinical_trials Límite: Humans / Infant Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lactancia Materna / Glucolípidos / Glicoproteínas / Fórmulas Infantiles / Microbioma Gastrointestinal Tipo de estudio: Clinical_trials Límite: Humans / Infant Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania