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Next-Generation Antibiotics, Bacteriophage Endolysins, and Nanomaterials for Combating Pathogens.
Shemyakin, I G; Firstova, V V; Fursova, N K; Abaev, I V; Filippovich, S Yu; Ignatov, S G; Dyatlov, I A.
Afiliación
  • Shemyakin IG; State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, 142279, Russia.
  • Firstova VV; State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, 142279, Russia. firstova@obolensk.org.
  • Fursova NK; State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, 142279, Russia.
  • Abaev IV; State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, 142279, Russia.
  • Filippovich SY; Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071, Russia.
  • Ignatov SG; State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, 142279, Russia.
  • Dyatlov IA; State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, 142279, Russia.
Biochemistry (Mosc) ; 85(11): 1374-1388, 2020 Nov.
Article en En | MEDLINE | ID: mdl-33280580
This review presents various strategies to fight causative agents of infectious diseases. Species-specific programmable RNA-containing antibiotics open up new possibilities for creating next-generation of personalized drugs based on microbiome editing and can serve as a new tool for selective elimination of pathogenic bacterial species while keeping intact the rest of microbiota. Another promising approach in combating bacterial infections is genome editing using the CRISPR-Cas systems. Expanding knowledge on the molecular mechanisms of innate immunity has been actively used for developing new antimicrobials. However, obvious risks of using antibiotic adjuvants aimed at activation of the host immune system include development of the autoimmune response with subsequent organ damage. To avoid these risks, it is essential to elucidate action mechanisms of the specific ligands and signal molecules used as components of the hybrid antibiotics. Bacteriophage endolysins are also considered as effective antimicrobials against antibiotic-resistant bacteria, metabolically inactive persisters, and microbial biofilms. Despite significant advances in the design of implants with antibacterial properties, the problem of postoperative infections still remains. Different nanomodifications of the implant surface have been designed to reduce bacterial contamination. Here, we review bactericidal, fungicidal, and immunomodulating properties of compounds used for the implant surface nanomodifications, such as silver, boron nitride nanomaterials, nanofibers, and nanogalvanic materials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Bacteriófagos / Proteínas Virales / Nanoestructuras / Antibacterianos Idioma: En Revista: Biochemistry (Mosc) Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Bacteriófagos / Proteínas Virales / Nanoestructuras / Antibacterianos Idioma: En Revista: Biochemistry (Mosc) Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos