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Loss of Furin in ß-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to ß-Cell Dysfunction.
Brouwers, Bas; Coppola, Ilaria; Vints, Katlijn; Dislich, Bastian; Jouvet, Nathalie; Van Lommel, Leentje; Segers, Charlotte; Gounko, Natalia V; Thorrez, Lieven; Schuit, Frans; Lichtenthaler, Stefan F; Estall, Jennifer L; Declercq, Jeroen; Ramos-Molina, Bruno; Creemers, John W M.
Afiliación
  • Brouwers B; Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
  • Coppola I; Metabolic Research Laboratories, Wellcome Trust Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
  • Vints K; Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
  • Dislich B; Electron Microscopy Platform and Vlaams Instituut voor Biotechnologie (VIB) Bioimaging Core, VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Jouvet N; Leuven Brain Institute, Department of Neurosciences, KU Leuven, Leuven, Belgium.
  • Van Lommel L; German Center for Neurodegenerative Diseases, Munich, Germany.
  • Segers C; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Gounko NV; Institut de recherches cliniques de Montréal, Montréal, Quebec, Canada.
  • Thorrez L; Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
  • Schuit F; Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
  • Lichtenthaler SF; Interdisciplinary Biosciences Group, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgium.
  • Estall JL; Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium.
  • Declercq J; Electron Microscopy Platform and Vlaams Instituut voor Biotechnologie (VIB) Bioimaging Core, VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Ramos-Molina B; Leuven Brain Institute, Department of Neurosciences, KU Leuven, Leuven, Belgium.
  • Creemers JWM; Department of Development and Regeneration, Campus Kulak, KU Leuven, Kortrijk, Belgium.
Diabetes ; 70(2): 492-503, 2021 02.
Article en En | MEDLINE | ID: mdl-33277337
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Furina / Células Secretoras de Insulina / Factor de Transcripción Activador 4 / Diana Mecanicista del Complejo 1 de la Rapamicina Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Diabetes Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Furina / Células Secretoras de Insulina / Factor de Transcripción Activador 4 / Diana Mecanicista del Complejo 1 de la Rapamicina Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Diabetes Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos