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The cross-sectional association between mean corpuscular volume level and cognitive function in Chinese over 45 years old: Evidence from the China Health and Retirement Longitudinal Study.
Chen, Yao; Ma, Chen'Xi' Nan; Luo, Lan; Yin, Jieyun; Gao, Zhan; Yu, Zengli; Wan, Zhongxiao.
Afiliación
  • Chen Y; College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
  • Ma CN; School of Public Health, Medical College of Soochow University, Suzhou, China.
  • Luo L; School of Public Health, Medical College of Soochow University, Suzhou, China.
  • Yin J; School of Public Health, Medical College of Soochow University, Suzhou, China.
  • Gao Z; The Fifth Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
  • Yu Z; College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
  • Wan Z; College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
PLoS One ; 15(12): e0243227, 2020.
Article en En | MEDLINE | ID: mdl-33270788
Fewer studies have focused on the independent association between mean corpuscular volume (MCV) and cognitive performance. This study was designed to characterize the cross-sectional association between MCV and cognitive performance in a large sample of Chinese residents (age≥45 years) from the China Health and Retirement Longitudinal Study (CHARLS). A total of 4023 male and 4173 female adults with MCV ≥ 80 fl were included for analysis. By multivariable linear regression analysis, for the total subjects, MCV level was significantly negatively associated with global cognitive function and episodic memory. When adjusted by sex, only in male subjects, higher MCV level was associated with reduced scores for global cognitive function, episodic memory and mental status. Via binary logistic regression analysis, the higher MCV level (MCV>100 fl) was associated with poor global cognitive function (OR = 1.601; 95% CI = 1.198-2.139; p = 0.001), episodic memory (OR = 1.679; 95% CI = 1.281-2.201; p<0.001), and mental status (OR = 1.422; 95% CI = 1.032-1.959; p = 0.031) for the whole participants. When testing this association by sex, the significant relationship between higher MCV level with worse episodic memory was observed both in male (OR = 1.690; 95% CI = 1.211-2.358; p = 0.002) and female (OR = 1.729; 95% CI = 1.079-2.770; p = 0.023) subjects; while the association between higher MCV level and poor global cognitive function (OR = 1.885; 95% CI = 1.329, 2.675; p<0.001) and mental status (OR = 1.544; 95% CI = 1.034, 2.306; p = 0.034) only existed in male subjects. Further studies are warranted to clarify the association between MCV level and cognitive performance by considering sex into consideration both cross-sectionally and longitudinally.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cognición / Índices de Eritrocitos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cognición / Índices de Eritrocitos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos