Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter.

Jia, Ruyu; Martens, Chloe; Shekhar, Mrinal; Pant, Shashank; Pellowe, Grant A; Lau, Andy M; Findlay, Heather E; Harris, Nicola J; Tajkhorshid, Emad; Booth, Paula J; Politis, Argyris

Jia, Ruyu; Martens, Chloe; Shekhar, Mrinal; Pant, Shashank; Pellowe, Grant A; Lau, Andy M; Findlay, Heather E; Harris, Nicola J; Tajkhorshid, Emad; Booth, Paula J; Politis, Argyris.

Afiliación

Jia R; Department of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK.
Martens C; Department of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. chloe.martens@ulb.be.
Shekhar M; Center for Structural Biology and Bioinformatics, Universite Libre de Bruxelles, Brussels, Belgium. chloe.martens@ulb.be.
Pant S; Center for Biophysics and Quantitative Biology, Department of Biochemistry, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Pellowe GA; Center for Biophysics and Quantitative Biology, Department of Biochemistry, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Lau AM; Department of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK.
Findlay HE; Department of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK.
Harris NJ; Department of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK.
Tajkhorshid E; Department of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK.
Booth PJ; Center for Biophysics and Quantitative Biology, Department of Biochemistry, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Politis A; Department of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. paula.booth@kcl.ac.uk.

Nat Commun ; 11(1): 6162, 2020 12 02.

Article en En | MEDLINE | ID: mdl-33268777

Asunto(s)

Proteínas de Escherichia coli/química; Glucosa/química; Protones; Simportadores/química; Xilosa/química; Sitios de Unión; Clonación Molecular; Cristalografía por Rayos X; Medición de Intercambio de Deuterio; Escherichia coli/genética; Escherichia coli/metabolismo; Proteínas de Escherichia coli/antagonistas & inhibidores; Proteínas de Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo; Expresión Génica; Vectores Genéticos/química; Vectores Genéticos/metabolismo; Glucosa/metabolismo; Espectrometría de Masas de Intercambio de Hidrógeno-Deuterio; Cinética; Simulación de Dinámica Molecular; Mutación; Unión Proteica; Conformación Proteica en Hélice alfa; Conformación Proteica en Lámina beta; Dominios y Motivos de Interacción de Proteínas; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Especificidad por Sustrato; Simportadores/antagonistas & inhibidores; Simportadores/genética; Simportadores/metabolismo; Termodinámica; Xilosa/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protones / Xilosa / Proteínas de Escherichia coli / Simportadores / Glucosa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

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