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Risk of Depression in Patients With Psoriatic Disease: A Systematic Review and Meta-Analysis.
Lukmanji, Aysha; Basmadjian, Robert B; Vallerand, Isabelle A; Patten, Scott B; Tang, Karen L.
Afiliación
  • Lukmanji A; 2129 Department of Community Health Sciences, University of Calgary, AB, Canada.
  • Basmadjian RB; 2129 Department of Community Health Sciences, University of Calgary, AB, Canada.
  • Vallerand IA; 2129 Department of Medicine, University of Calgary, AB, Canada.
  • Patten SB; 70401 Division of Dermatology, University of Calgary, AB, Canada.
  • Tang KL; 2129 Department of Community Health Sciences, University of Calgary, AB, Canada.
J Cutan Med Surg ; 25(3): 257-270, 2021.
Article en En | MEDLINE | ID: mdl-33263264
BACKGROUND: Previous systematic reviews have assessed the prevalence and odds ratio (OR) of depression for patients with psoriatic disease. Due to probable bidirectional effects, prevalence and prevalence ORs are difficult to interpret. No prior reviews have quantified the relative risk (RR) of depression following a diagnosis of psoriatic disease. OBJECTIVE: To estimate the RR of depression in individuals with psoriasis and in psoriatic arthritis (PsA), clear-to-moderate psoriasis, and moderate-to-severe psoriasis subgroups. METHODS: Observational studies investigating the risk of depression in adults with psoriatic disease were systematically searched for in Medline, EMBASE, PsycINFO, and CINAHL databases; 4989 unique references were screened. Studies that reported measures of incident depression in psoriasis patients were included. Thirty-one studies were included into the systematic review, of which 17 were meta-analyzed. Random effects models were employed to synthesize relevant data. Sources of heterogeneity were explored with subgroup analysis and meta-regression. RESULTS: Seventeen studies were included in meta-analyses. The pooled RR of depression in psoriasis patients compared to nonpsoriasis controls was 1.48 (95% CI: 1.16-1.89). Heterogeneity was high (I2 = 99.8%). Subgroup analysis and meta-regression did not indicate that PsA status or psoriasis severity (clear-to-mild, moderate-to-severe) were sources of heterogeneity. No evidence of publication bias was found. CONCLUSIONS: This review demonstrates that the risk of depression is greater in patients with psoriasis and PsA. Future research should focus on developing strategies to address the mental health needs of this patient population for depression, including primary prevention, earlier detection, and treatment strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Depresión Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Humans Idioma: En Revista: J Cutan Med Surg Asunto de la revista: DERMATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Depresión Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Humans Idioma: En Revista: J Cutan Med Surg Asunto de la revista: DERMATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos