Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature.

Tavor, Sigal; Shalit, Tali; Chapal Ilani, Noa; Moskovitz, Yoni; Livnat, Nir; Groner, Yoram; Barr, Haim; Minden, Mark D; Plotnikov, Alexander; Deininger, Michael W; Kaushansky, Nathali; Shlush, Liran I

Tavor, Sigal; Shalit, Tali; Chapal Ilani, Noa; Moskovitz, Yoni; Livnat, Nir; Groner, Yoram; Barr, Haim; Minden, Mark D; Plotnikov, Alexander; Deininger, Michael W; Kaushansky, Nathali; Shlush, Liran I.

Afiliación

Tavor S; Hemato-Oncology Department, Assuta Medical Center, Tel Aviv, Israel.
Shalit T; G-INCPM, Weizmann Institute of Science, Rehovot, Israel.
Chapal Ilani N; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Moskovitz Y; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Livnat N; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Groner Y; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Barr H; G-INCPM, Weizmann Institute of Science, Rehovot, Israel.
Minden MD; Princess Margaret Cancer Centre, University Health Network (UHN) Toronto, Canada.
Plotnikov A; G-INCPM, Weizmann Institute of Science, Rehovot, Israel.
Deininger MW; Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT, USA.
Kaushansky N; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Shlush LI; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.

Haematologica ; 105(12): 2795-2804, 2020 12 01.

Article en En | MEDLINE | ID: mdl-33256378

Asunto(s)

Leucemia Mieloide Aguda; Inhibidores de Proteínas Quinasas; Animales; Dasatinib/farmacología; Humanos; Leucemia Mieloide Aguda/tratamiento farmacológico; Leucemia Mieloide Aguda/genética; Ratones; Mutación; Inhibidores de Proteínas Quinasas/farmacología; Inhibidores de Proteínas Quinasas/uso terapéutico; Proteína Tirosina Fosfatasa no Receptora Tipo 11; Transcriptoma; Tirosina Quinasa 3 Similar a fms/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Haematologica Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Italia

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