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Rumen and Serum Metabolomes in Response to Endophyte-Infected Tall Fescue Seed and Isoflavone Supplementation in Beef Steers.
Ault-Seay, Taylor B; Melchior-Tiffany, Emily A; Clemmons, Brooke A; Cordero, Juan F; Bates, Gary E; Flythe, Michael D; Klotz, James L; Ji, Huihua; Goodman, Jack P; McLean, Kyle J; Myer, Phillip R.
Afiliación
  • Ault-Seay TB; Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA.
  • Melchior-Tiffany EA; Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA.
  • Clemmons BA; Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA.
  • Cordero JF; Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA.
  • Bates GE; Department of Plant Sciences, University of Tennessee, Knoxville, TN 37996, USA.
  • Flythe MD; USDA-ARS, Forage-Animal Production Research Unit, Lexington, KY 40546, USA.
  • Klotz JL; USDA-ARS, Forage-Animal Production Research Unit, Lexington, KY 40546, USA.
  • Ji H; Kentucky Tobacco Research and Development Center, University of Kentucky, Lexington, KY 40546, USA.
  • Goodman JP; Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546, USA.
  • McLean KJ; Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA.
  • Myer PR; Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA.
Toxins (Basel) ; 12(12)2020 11 26.
Article en En | MEDLINE | ID: mdl-33256042
Fescue toxicosis impacts beef cattle production via reductions in weight gain and muscle development. Isoflavone supplementation has displayed potential for mitigating these effects. The objective of the current study was to evaluate isoflavone supplementation with fescue seed consumption on rumen and serum metabolomes. Angus steers (n = 36) were allocated randomly in a 2 × 2 factorial arrangement of treatments including endophyte-infected (E+) or endophyte-free (E-) tall fescue seed, with (P+) or without (P-) isoflavones. Steers were provided a basal diet with fescue seed for 21 days, while isoflavones were orally administered daily. Following the trial, blood and rumen fluid were collected for metabolite analysis. Metabolites were extracted and then analyzed by UPLC-MS. The MAVEN program was implemented to identify metabolites for MetaboAnalyst 4.0 and SAS 9.4 statistical analysis. Seven differentially abundant metabolites were identified in serum by isoflavone treatment, and eleven metabolites in the rumen due to seed type (p < 0.05). Pathways affected by treatments were related to amino acid and nucleic acid metabolism in both rumen fluid and serum (p < 0.05). Therefore, metabolism was altered by fescue seed in the rumen; however, isoflavones altered metabolism systemically to potentially mitigate detrimental effects of seed and improve animal performance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rumen / Suero / Metaboloma / Isoflavonas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Toxins (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rumen / Suero / Metaboloma / Isoflavonas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Toxins (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza