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Current Fertility Preservation Options for Female Patients With Hodgkin Lymphoma.
Hutchcraft, Megan L; McCracken, Kate; Whiteside, Stacy; Lustberg, Maryam; Lindheim, Steven R; Nahata, Leena; Appiah, Leslie C.
Afiliación
  • Hutchcraft ML; Attending Physician, Department of Obstetrics and Gynecology, Christie Clinic, Champaign, IL; Clinical Assistant Professor, Carle Illinois College of Medicine, Champaign, IL.
  • McCracken K; Assistant Professor, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH; Attending Physician, Department of Pediatric and Adolescent Gynecology.
  • Whiteside S; Nurse Practitioner, Department of Pediatric Hematology, Oncology, and Bone Marrow Transplantation, Nationwide Children's Hospital, Columbus, OH.
  • Lustberg M; Associate Professor of Medicine, Department of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH.
  • Lindheim SR; Clinical Professor, Wright State University Boonshoft School of Medicine, Dayton, OH; Visiting Professor, Department of Reproductive Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China.
  • Nahata L; Attending Physician, Department of Pediatric Endocrinology, Nationwide Children's Hospital, Columbus, OH; Associate Professor of Clinical Pediatrics, The Ohio State University College of Medicine, Columbus, OH.
  • Appiah LC; Associate Professor, Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, Colorado Comprehensive Cancer Center and Children's Hospital of Colorado, The University of Colorado School of Medicine, Aurora, CO.
Obstet Gynecol Surv ; 75(11): 683-691, 2020 Nov.
Article en En | MEDLINE | ID: mdl-33252698
IMPORTANCE: Many adolescents and young adults diagnosed with Hodgkin lymphoma (HL) experience disease progression requiring high-dose alkylating salvage therapy, which often results in permanent infertility. OBJECTIVE: The aim of this report is to discuss fertility preservation options in female patients with consideration of chemotherapeutic agents in HL. EVIDENCE ACQUISITION: An electronic literature review was performed utilizing a combination of the terms "Hodgkin lymphoma," "fertility preservation," "ovarian tissue cryopreservation," "oocyte cryopreservation," "embryo cryopreservation," and "gonadotropin-releasing hormone agonist." References and data from identified sources were searched and compiled to complete this review. RESULTS: Initial treatment of HL is often nonsterilizing; however, salvage therapy and conditioning for stem cell transplantation confer significant gonadotoxicity. Established fertility preservation options for pubertal females include embryo cryopreservation and oocyte cryopreservation. These options are contraindicated within 6 months of receipt of chemotherapy. Ovarian tissue cryopreservation is an option for patients who require salvage therapy within 6 months of first-line therapy. CONCLUSIONS: Timing and choice of fertility preservation techniques depends on planned first-line chemotherapy and response to treatment. In patients initially treated with low-risk chemotherapy, it is reasonable to defer invasive fertility techniques until treatment failure; however, upfront fertility preservation should be considered in patients planning to undergo primary treatment with high-risk therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Antineoplásicos Alquilantes / Preservación de la Fertilidad / Infertilidad Femenina Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Obstet Gynecol Surv Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Antineoplásicos Alquilantes / Preservación de la Fertilidad / Infertilidad Femenina Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Obstet Gynecol Surv Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos