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Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in in vitro and in vivo Models of Neurodegenerative Diseases.
Masmoudi-Kouki, Olfa; Namsi, Amira; Hamdi, Yosra; Bahdoudi, Seyma; Ghouili, Ikram; Chuquet, Julien; Leprince, Jérôme; Lefranc, Benjamin; Ghrairi, Taoufik; Tonon, Marie-Christine; Lizard, Gérard; Vaudry, David.
Afiliación
  • Masmoudi-Kouki O; Laboratory of Neurophysiology Cellular Physiopathology and Biomolecule Valorisation, LR18ES03, Faculty of Sciences of Tunis, University Tunis El Manar, Tunis, Tunisia.
  • Namsi A; Laboratory of Neurophysiology Cellular Physiopathology and Biomolecule Valorisation, LR18ES03, Faculty of Sciences of Tunis, University Tunis El Manar, Tunis, Tunisia.
  • Hamdi Y; Team Bio-PeroxIL, Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism/University Bourgogne Franche-Comté (UBFC)/Inserm, Dijon, France.
  • Bahdoudi S; Laboratory of Neurophysiology Cellular Physiopathology and Biomolecule Valorisation, LR18ES03, Faculty of Sciences of Tunis, University Tunis El Manar, Tunis, Tunisia.
  • Ghouili I; Laboratory of Neurophysiology Cellular Physiopathology and Biomolecule Valorisation, LR18ES03, Faculty of Sciences of Tunis, University Tunis El Manar, Tunis, Tunisia.
  • Chuquet J; Normandy University, Neuronal and Neuroendocrine Differentiation and Communication, Inserm U1239, Rouen, France.
  • Leprince J; Laboratory of Neurophysiology Cellular Physiopathology and Biomolecule Valorisation, LR18ES03, Faculty of Sciences of Tunis, University Tunis El Manar, Tunis, Tunisia.
  • Lefranc B; Normandy University, Neuronal and Neuroendocrine Differentiation and Communication, Inserm U1239, Rouen, France.
  • Ghrairi T; Normandy University, Neuronal and Neuroendocrine Differentiation and Communication, Inserm U1239, Rouen, France.
  • Tonon MC; Normandy University, Regional Platform for Cell Imaging of Normandy (PRIMACEN), Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France.
  • Lizard G; Normandy University, Neuronal and Neuroendocrine Differentiation and Communication, Inserm U1239, Rouen, France.
  • Vaudry D; Normandy University, Regional Platform for Cell Imaging of Normandy (PRIMACEN), Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France.
Front Endocrinol (Lausanne) ; 11: 566026, 2020.
Article en En | MEDLINE | ID: mdl-33250858
Octadecaneuropeptide (ODN) and its precursor diazepam-binding inhibitor (DBI) are peptides belonging to the family of endozepines. Endozepines are exclusively produced by astroglial cells in the central nervous system of mammals, and their release is regulated by stress signals and neuroactive compounds. There is now compelling evidence that the gliopeptide ODN protects cultured neurons and astrocytes from apoptotic cell death induced by various neurotoxic agents. In vivo, ODN causes a very strong neuroprotective action against neuronal degeneration in a mouse model of Parkinson's disease. The neuroprotective activity of ODN is based on its capacity to reduce inflammation, apoptosis, and oxidative stress. The protective effects of ODN are mediated through its metabotropic receptor. This receptor activates a transduction cascade of second messengers to stimulate protein kinase A (PKA), protein kinase C (PKC), and mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK) signaling pathways, which in turn inhibits the expression of proapoptotic factor Bax and the mitochondrial apoptotic pathway. In N2a cells, ODN also promotes survival and stimulates neurite outgrowth. During the ODN-induced neuronal differentiation process, numerous mitochondria and peroxisomes are identified in the neurites and an increase in the amount of cholesterol and fatty acids is observed. The antiapoptotic and neurotrophic properties of ODN, including its antioxidant, antiapoptotic, and pro-differentiating effects, suggest that this gliopeptide and some of its selective and stable derivatives may have therapeutic value for the treatment of some neurodegenerative diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Neuropéptidos / Fármacos Neuroprotectores / Enfermedades Neurodegenerativas / Citoprotección / Inhibidor de la Unión a Diazepam / Modelos Animales de Enfermedad / Neuroprotección Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2020 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Neuropéptidos / Fármacos Neuroprotectores / Enfermedades Neurodegenerativas / Citoprotección / Inhibidor de la Unión a Diazepam / Modelos Animales de Enfermedad / Neuroprotección Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2020 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Suiza