The staphylococcal exopolysaccharide PIA - Biosynthesis and role in biofilm formation, colonization, and infection.
Comput Struct Biotechnol J
; 18: 3324-3334, 2020.
Article
en En
| MEDLINE
| ID: mdl-33240473
Exopolysaccharide is a key part of the extracellular matrix that contributes to important mechanisms of bacterial pathogenicity, most notably biofilm formation and immune evasion. In the human pathogens Staphylococcus aureus and S. epidermidis, as well as in many other staphylococcal species, the only exopolysaccharide is polysaccharide intercellular adhesin (PIA), a cationic, partially deacetylated homopolymer of N-acetylglucosamine, whose biosynthetic machinery is encoded in the ica locus. PIA production is strongly dependent on environmental conditions and controlled by many regulatory systems. PIA contributes significantly to staphylococcal biofilm formation and immune evasion mechanisms, such as resistance to antimicrobial peptides and ingestion and killing by phagocytes, and presence of the ica genes is associated with infectivity. Due to its role in pathogenesis, PIA has raised considerable interest as a potential vaccine component or target.
Biofilm; CoNS, coagulase-negative staphylococci; Colonization; Device-related infection; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus; PIA; PIA, polysaccharide intercellular adhesin; PNAG; PNAG, poly-N-acetylglucosamine; Poly-N-acetylglucosamine; Polysaccharide intercellular adhesin; Staphylococcus aureus; Staphylococcus epidermidis
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Comput Struct Biotechnol J
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Países Bajos