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Early symptomatic neurosyphilis and ocular syphilis: A comparative study between HIV-positive and HIV-negative patients.
Rasoldier, V; Gueudry, J; Chapuzet, C; Bodaghi, B; Muraine, M; Tubiana, R; Paris, L; Pestel-Caron, M; Caron, F; Caumes, E.
Afiliación
  • Rasoldier V; CHU Charles Nicolle, Service des Maladies infectieuses et Tropicales, 1, rue de Germont, 76000 Rouen, France. Electronic address: vero.rasoldier@chu-rouen.fr.
  • Gueudry J; CHU Charles Nicolle, Service d'ophtalmologie, 1, rue de Germont, 76000 Rouen, France.
  • Chapuzet C; CHU Charles Nicolle, Service des Maladies infectieuses et Tropicales, 1, rue de Germont, 76000 Rouen, France.
  • Bodaghi B; AP-HP, Hôpital la Pitié Salpêtrière, Service ophtalmologie, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
  • Muraine M; CHU Charles Nicolle, Service d'ophtalmologie, 1, rue de Germont, 76000 Rouen, France.
  • Tubiana R; Sorbonne Université, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Service de Maladies infectieuses et Tropicales, 75013 Paris, France; AP-HP, Hôpital la Pitié Salpêtrière, Service des Maladies Infectieuses et Tropicales, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
  • Paris L; AP-HP, Hôpitaux universitaires la Pitié Salpêtrière/Charles Foix, Pôle biologie et pathologie, Service de parasitologie, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
  • Pestel-Caron M; CHU Charles Nicolle, Institut de Biologie Clinique, Service de Bactériologie, 1, rue de Germont, 76000 Rouen, France.
  • Caron F; CHU Charles Nicolle, Service des Maladies infectieuses et Tropicales, 1, rue de Germont, 76000 Rouen, France.
  • Caumes E; AP-HP, Hôpital la Pitié Salpêtrière, Service des Maladies Infectieuses et Tropicales, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Sorbonne Université, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Service de Maladies infectieuses et Tropicales, 75013 Paris, France; Sorbonne
Infect Dis Now ; 51(4): 351-356, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33239175
OBJECTIVES: Since the 2000s, there has been an increase in prevalence of neurosyphilis (NS) and ocular syphilis (OS). As data about symptomatic NS/OS is limited, this study aims to assess the characteristics of symptomatic NS/OS, according to HIV status. METHODS: We compared the clinical and biological presentation of early symptomatic NS/OS and its outcome in HIV-positive and HIV-negative patients. RESULTS: Ninety-six patients (93% men, 49% HIV-positive) were included from 2000 to 2016 in two centers, with 67 (69%) having OS, 15 (16%) NS, and 14 (14%) both. HIV-positive patients were younger (P=0.006) and more likely to be males having sex with males (P=0.00048) or to have a history of syphilis (P=0.01). Among 81 OS, there were 43 posterior uveitis (57%), and bilateral involvement was more common in HIV-positive patients (62% versus 38%, P=0.045). Among 29 NS there were 21 cases of cranial nerve involvement (72%), seven meningitis (24%) and 11 paresthesia (38%). Involvement of the VIIIth cranial nerve was the most common (16 cases). Treponemal tests were more commonly found positive in cerebrospinal fluid in HIV-positive patients (88% versus 76%, P=0.04). Visual acuity (VA) always improved after treatment (initial VA logMAR 0.8±0.8 versus 0.1±0.1 at 3 months), but 32% and 18% of the patients still had neurological or ocular impairment respectively six and 12 months after treatment. Non-treponemal serological reversion was observed in 43/50 patients (88%) at six months. CONCLUSION: HIV infection has no consequence on the outcome of NS and OS. Sequelae are common, emphasizing the importance of prevention, and screening, and questioning enhanced treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sífilis / Infecciones Bacterianas del Ojo / Infecciones por VIH / Neurosífilis Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Infect Dis Now Año: 2021 Tipo del documento: Article Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sífilis / Infecciones Bacterianas del Ojo / Infecciones por VIH / Neurosífilis Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Infect Dis Now Año: 2021 Tipo del documento: Article Pais de publicación: Francia