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Blocking of Transient Receptor Potential Vanilloid 1 (TRPV1) promotes terminal mitophagy in multiple myeloma, disturbing calcium homeostasis and targeting ubiquitin pathway and bortezomib-induced unfolded protein response.
Beider, Katia; Rosenberg, Evgenia; Dimenshtein-Voevoda, Valeria; Sirovsky, Yaarit; Vladimirsky, Julia; Magen, Hila; Ostrovsky, Olga; Shimoni, Avichai; Bromberg, Zohar; Weiss, Lola; Peled, Amnon; Nagler, Arnon.
Afiliación
  • Beider K; Division of Hematology, CBB and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel.
  • Rosenberg E; Division of Hematology, CBB and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel.
  • Dimenshtein-Voevoda V; Division of Hematology, CBB and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel.
  • Sirovsky Y; Division of Hematology, CBB and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel.
  • Vladimirsky J; Division of Hematology, CBB and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel.
  • Magen H; Division of Hematology, CBB and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel.
  • Ostrovsky O; Division of Hematology, CBB and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel.
  • Shimoni A; Division of Hematology, CBB and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel.
  • Bromberg Z; Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, Jerusalem, Israel.
  • Weiss L; Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, Jerusalem, Israel.
  • Peled A; Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, Jerusalem, Israel.
  • Nagler A; Division of Hematology, CBB and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel. a.nagler@sheba.health.gov.il.
J Hematol Oncol ; 13(1): 158, 2020 11 25.
Article en En | MEDLINE | ID: mdl-33239060
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acrilamidas / Compuestos Bicíclicos Heterocíclicos con Puentes / Canales Catiónicos TRPV / Mitofagia / Bortezomib / Mieloma Múltiple / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acrilamidas / Compuestos Bicíclicos Heterocíclicos con Puentes / Canales Catiónicos TRPV / Mitofagia / Bortezomib / Mieloma Múltiple / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido