What Are the Live Birth and Multiple Pregnancy Rates When 1 Versus 2 Low-Quality Blastocysts Are Transferred in a Cryopreserved Cycle? a Retrospective Cohort Study, Stratified for Age, Embryo Quality, and Oocyte Donor Cycles.

Arab, Suha; Badegiesh, Ahmad; Aldhaheri, Sarah; Son, Weon-Young; Dahan, Michael H

Arab, Suha; Badegiesh, Ahmad; Aldhaheri, Sarah; Son, Weon-Young; Dahan, Michael H.

Afiliación

Arab S; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility Center, McGill University, 888 Boulevard de Maisonneuve East, suit # 200, Montreal, Quebec, H2l 4S8, Canada. suhaarab@gmail.com.
Badegiesh A; Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Aldhaheri S; Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Son WY; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility Center, McGill University, 888 Boulevard de Maisonneuve East, suit # 200, Montreal, Quebec, H2l 4S8, Canada.
Dahan MH; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility Center, McGill University, 888 Boulevard de Maisonneuve East, suit # 200, Montreal, Quebec, H2l 4S8, Canada.

Reprod Sci ; 28(5): 1403-1411, 2021 05.

Article en En | MEDLINE | ID: mdl-33237513

RESUMEN

Outcomes among women who transferred only Gardner's grade BB or lower quality frozen embryos transferred (FET) are not well known. Our objective is to study whether transferring 2 versus 1 frozen low-quality blastocysts will increase the live birth rate (LBR) and the multiple pregnancy rate (MPR). This is a retrospective cohort study including 1104 FET cycles. Only day 5-6 blastocysts of grade BB or lower quality were included. Clinical pregnancy rate (CPR), MPR, and LBR per cycle were compared between single embryo transfer (SET) (n = 969) and double embryo transfer (DET) (n = 135). CPR and MPR were compared between SET and DET in grade BB, BC, CB, and CC individually. Among SET, BB blastocysts had higher CPR 34% (P = 0.0001) and a sub-significant increase in LBR 19% (P = 0.059) in comparison to other grade SET. Among all BB, MPR was significantly higher when transferring two versus one (5.9 vs. 1.9, P = 0.009). If age at egg collection ≥ 40 years (n = 97), no difference was found in CPR (11.1 vs. 11.7, P = 0.9), MPR (0 vs. 0), and LBR (6.3 vs. 0,P = 0.13) when SET or DET was performed. If age was < 40 years (n = 818), the MPR was significantly higher in DET than SET (6.7 vs. 1.63, P = 0.004). In egg donor cycles (n = 189), there was no difference in CPR, MPR, and LBR between SET and DET. Single embryo transfer should be offered even in women ≥ 40 years of age or transferring lower quality embryos since transferring more did not increase outcomes in this group, and SET is likely the safest path.

Asunto(s)

Tasa de Natalidad; Transferencia de Embrión/métodos; Nacimiento Vivo; Embarazo Múltiple; Adulto; Blastómeros/fisiología; Criopreservación; Femenino; Humanos; Oocitos/fisiología; Embarazo; Estudios Retrospectivos

Palabras clave

Double embryo transfer; Frozen blastocyst; IVF; Multiple pregnancy rates; Poor-quality embryo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embarazo Múltiple / Tasa de Natalidad / Transferencia de Embrión / Nacimiento Vivo Tipo de estudio: Etiology_studies / Observational_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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