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Endothelial Progenitor Cell CD34+ and CD133+ Concentrations and Soluble HLA-G Concentrations During Pregnancy and in Cord Blood in Undifferentiated Connective Tissue Diseases Compared to Controls.
Beneventi, Fausta; De Maggio, Irene; Cavagnoli, Chiara; Bellingeri, Camilla; Ruspini, Beatrice; Riceputi, Greta; Viarengo, Gianluca; Ramoni, Véronique; Spinillo, Arsenio.
Afiliación
  • Beneventi F; Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy.
  • De Maggio I; Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy. irene.demaggio2@gmail.com.
  • Cavagnoli C; Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy.
  • Bellingeri C; Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy.
  • Ruspini B; Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy.
  • Riceputi G; Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy.
  • Viarengo G; Immunohaematology and Transfusion Service, IRCCS Foundation Policlinico San Matteo, 27100, Pavia, Italy.
  • Ramoni V; Division of Rheumatology, IRCCS Foundation Policlinico San Matteo, University of Pavia, 27100, Pavia, Italy.
  • Spinillo A; Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy.
Reprod Sci ; 28(5): 1382-1389, 2021 05.
Article en En | MEDLINE | ID: mdl-33237511
The objective of this study is to evaluate endothelial progenitor cells (EPCs) CD34+ CD133- and CD34+ CD133+ and soluble HLA-G (sHLA-G) concentrations among undifferentiated connective tissue disease (UCTD) subjects, compared to controls, during pregnancy and in cord blood. This is a case-control study including 29 controls and 29 UCTDs. CD34+ CD133-, CD34+ CD133+, and sHLA-G concentrations were detected in maternal plasma and in cord blood. This study was approved by the Medical-Ethical Committee of our Institution (Current Research Project N. 901-rcr2017i-23 of IRCCS Foundation Policlinico San Matteo of Pavia). Circulating CD34+ CD133- and CD34+ CD133+ counts and sHLA-G (soluble human leucocyte antigen G) concentrations in maternal peripherical blood were higher in UCTD compared to those in controls in first and third trimester of pregnancy and at delivery (p < 0.001). Maternal CD34+ CD133- and CD34+ CD133+ counts were strongly and significantly correlated in UCTD (Spearman's rho = 0.79, p < 0.0001) but not in controls (Spearman's rho = 0.10, p = 0.35). Cord blood CD34+ CD133- and CD34+ CD133+ median counts and median sHLA-G concentrations were higher among UCTD subjects than in controls (p < 0.001). Cord blood CD34+ and CD133+ counts were inversely and significantly correlated with sHLA-G concentrations among UCTDs, but not in controls. Early UCTD is characterized by increased EPC levels in maternal plasma and in cord blood and higher levels of sHLA-G, compared to controls. Data suggest that fetoplacental unit plays an independent role in the EPC response to a systemic autoimmune disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos CD34 / Sangre Fetal / Antígenos HLA-G / Células Progenitoras Endoteliales / Antígeno AC133 / Enfermedades Indiferenciadas del Tejido Conectivo Tipo de estudio: Observational_studies Aspecto: Ethics Límite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos CD34 / Sangre Fetal / Antígenos HLA-G / Células Progenitoras Endoteliales / Antígeno AC133 / Enfermedades Indiferenciadas del Tejido Conectivo Tipo de estudio: Observational_studies Aspecto: Ethics Límite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos