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Association of Complicated Diverticulitis With Development of De Novo Inflammatory Bowel Disease.
Ur Rahman, Asad; Hussain, Ishtiaq; Hasan, Badar; Ur Rashid, Mamoon; Tandon, Kanwarpreet Singh; Castro, Fernando.
Afiliación
  • Ur Rahman A; Department of Gastroenterology, Cleveland Clinic Florida, Weston, Florida, USA.
  • Hussain I; Department of Gastroenterology, Cleveland Clinic Florida, Weston, Florida, USA.
  • Hasan B; Department of Gastroenterology, Cleveland Clinic Florida, Weston, Florida, USA.
  • Ur Rashid M; Department of Internal Medicine, Advent Health, Orlando, Florida, USA.
  • Tandon KS; Department of Gastroenterology, Cleveland Clinic Florida, Weston, Florida, USA.
  • Castro F; Department of Gastroenterology, Cleveland Clinic Florida, Weston, Florida, USA.
Inflamm Bowel Dis ; 27(7): 1061-1067, 2021 06 15.
Article en En | MEDLINE | ID: mdl-33237324
BACKGROUND: There has been a historic similarity in the epidemiology and pathophysiology of diverticular disease and inflammatory bowel disease (IBD). Because there are limited to no data on the role of diverticulitis as a potential risk factor for de novo IBD, we aimed to evaluate the role of diverticulitis and complicated diverticulitis as a potential predictor of IBD. METHODS: We performed a retrospective, single-center study including patients older than age 18 years who were diagnosed with diverticulitis from January 2012 until December 2018 without a prior diagnosis of IBD. These patients were then evaluated for development of IBD. Univariate and multivariate analyses were conducted to compare the characteristics and outcomes between patients who did or did not develop IBD. RESULTS: A total of 2770 patients were diagnosed with diverticulitis from 2012 until 2018. Of these patients, 17 were diagnosed with IBD, resulting in an incidence rate of 0.23% per patient-year. The incidence rate among patients who required surgery for diverticulitis was 0.44% per patient-year, and patients with complicated diverticulitis had an incidence rate of 0.91% per patient-year. Univariate analysis showed that the need for surgery related to diverticulitis (hazard ratio [HR], 6.27; P = 0.003) and complicated diverticulitis was associated with the development of IBD (HR, 14.71; P < 0.001). Multivariate analysis showed that complicated diverticulitis was the sole factor associated with IBD (HR, 10.34; P < 0.001). CONCLUSIONS: Patients with diverticulitis are at a higher risk of developing de novo IBD. This risk is highest in patients with complicated diverticulitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Diverticulitis Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Diverticulitis Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido