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Maternal H-antigen secretor status is an early biomarker for potential preterm delivery.
Caldwell, Jennifer; Matson, Adam; Mosha, Maua; Hagadorn, James I; Moore, James; Brownell, Elizabeth.
Afiliación
  • Caldwell J; Division of Neonatology, Connecticut Children's Medical Center, Hartford, CT, USA.
  • Matson A; Department of Pediatrics, Universityof Connecticut School of Medicine, Farmington, CT, USA.
  • Mosha M; Division of Neonatology, Connecticut Children's Medical Center, Hartford, CT, USA.
  • Hagadorn JI; Department of Pediatrics, Universityof Connecticut School of Medicine, Farmington, CT, USA.
  • Moore J; Department of Research, Connecticut Children's Medical Center, Hartford, CT, USA.
  • Brownell E; Division of Neonatology, Connecticut Children's Medical Center, Hartford, CT, USA.
J Perinatol ; 41(9): 2147-2155, 2021 09.
Article en En | MEDLINE | ID: mdl-33235282
OBJECTIVE: Pre-pregnancy or first trimester biomarkers predicting preterm delivery are lacking. The purpose of this study was to determine whether maternal H-antigen (secretor status) is a potential biomarker for preterm delivery. METHODS: This cohort study examined maternal saliva samples and birth data gathered by the National Children's Study Vanguard pilot phase (2009-2014) and included 300 women who were ≥18 years old and provided birth data and saliva samples. The maternal secretor status phenotype was determined by quantifying H-antigen in saliva using enzyme-linked immunoassay. Mothers were stratified by secretor status and multivariable analysis estimated adjusted associations with preterm delivery. RESULTS: Maternal lack of H-antigen production was an independent risk factor for preterm delivery after adjusting for known confounders (aOR 4.53; 95% CI: 1.74, 11.81; P = 0.002). CONCLUSIONS: Maternal H-antigen may be a biomarker identifying women at-risk for preterm delivery. Prospective cohort studies validating these findings are needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nacimiento Prematuro Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Female / Humans / Pregnancy Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nacimiento Prematuro Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Female / Humans / Pregnancy Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos