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Association between polymorphisms in the interleukin-10 gene and susceptibility to human immunodeficiency virus-1 infection: A systematic review and meta-analysis.
Fu, Dan-Hui; Deng, Wen-Juan; Yang, Zhi; Hong, Sen; Ding, Qian-Lin; Zhao, Yang; Chen, Jia; Su, Dan-Ke.
Afiliación
  • Fu DH; Department of Radiology.
  • Deng WJ; Department of Radiology.
  • Yang Z; Department of Nuclear Medicine, Tumor Hospital Affiliated to Guangxi Medical University, Nanning, China.
  • Hong S; Department of Radiology.
  • Ding QL; Department of Radiology.
  • Zhao Y; Department of Radiology.
  • Chen J; Department of Radiology.
  • Su DK; Department of Radiology.
Medicine (Baltimore) ; 99(48): e23069, 2020 Nov 25.
Article en En | MEDLINE | ID: mdl-33235068
BACKGROUND: This study meta-analyzed the literature on possible association of 3 polymorphisms (-592, -1082, -819) in the interleukin-10 (IL-10) gene with susceptibility to human immunodeficiency virus (HIV)-1 infection. METHODS: PubMed, EMBASE, MEDLINE and Google Scholar were systematically searched to identify relevant studies in English. Meta-analyses were performed to examine the association of IL-10 polymorphisms -592, -1082, and -819 with susceptibility to HIV-1 infection. RESULTS: A significant association between the -592 polymorphism and susceptibility to HIV-1 infection was found in the total population (recessive model, odds ratios (OR) = 1.44, 95% CI = 1.06-1.96, P = .02; homozygous model, OR = 1.44, 95% CI = 1.02-2.02, P = .04). However, these results were not observed in subgroups based on ethnicity. The -1082 polymorphism was significantly associated with susceptibility to HIV-1 infection in Caucasians (OR = 1.30, 95% CI = 1.05-1.62, P = .02; recessive model, OR = 1.49, 95% CI = 1.09-2.03, P = .01; homozygous model, OR = 1.58, 95% CI = 1.01-2.46, P = .04), but not in Asians or the total population. None of the 5 genetic models suggested a significant association between the -819 polymorphism and HIV-1 infection. CONCLUSION: The available evidence indicates that the AA genotype of IL-10 -592 may confer increased susceptibility to HIV-1 infection, and that the AA genotype of -1082 may confer increased susceptibility in Caucasians. In contrast, the -819 polymorphism may not be associated with HIV-1 infection risk. These conclusions should be verified in large, well-designed studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Interleucina-10 / Predisposición Genética a la Enfermedad Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Medicine (Baltimore) Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Interleucina-10 / Predisposición Genética a la Enfermedad Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Medicine (Baltimore) Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos