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Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial.
Brown, Justin C; Rosenthal, Michael H; Ma, Chao; Zhang, Sui; Nimeiri, Halla S; McCleary, Nadine J; Abrams, Thomas A; Yurgelun, Matthew B; Cleary, James M; Rubinson, Douglas A; Schrag, Deborah; Bullock, Andrea J; Allen, Jill; Zuckerman, Dan; Chan, Emily; Chan, Jennifer A; Wolpin, Brian; Constantine, Michael; Weckstein, Douglas J; Faggen, Meredith A; Thomas, Christian A; Kournioti, Chryssanthi; Yuan, Chen; Zheng, Hui; Hollis, Bruce W; Fuchs, Charles S; Ng, Kimmie; Meyerhardt, Jeffrey A.
Afiliación
  • Brown JC; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
  • Rosenthal MH; LSU Health Sciences Center, New Orleans School of Medicine, New Orleans, LA 70012, USA.
  • Ma C; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70012, USA.
  • Zhang S; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Nimeiri HS; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • McCleary NJ; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Abrams TA; Division of Hematology Oncology, Department of Medicine, Northwestern University, Chicago, IL 60611, USA.
  • Yurgelun MB; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Cleary JM; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Rubinson DA; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Schrag D; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Bullock AJ; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Allen J; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Zuckerman D; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  • Chan E; Massachusetts General Hospital, Boston, MA 02114, USA.
  • Chan JA; St Luke's Mountain States Tumor Institute, Boise, ID 83712, USA.
  • Wolpin B; Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Constantine M; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Weckstein DJ; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Faggen MA; Dana-Farber at Milford Regional Medical Center, Milford, MA 01757, USA.
  • Thomas CA; New Hampshire Oncology Hematology, Hookset, NH 03106, USA.
  • Kournioti C; Dana-Farber at South Shore Hospital, South Weymouth, MA 02190, USA.
  • Yuan C; New England Cancer Specialists, Scarborough, ME 04074, USA.
  • Zheng H; Newton-Wellesley Hospital, Newton, MA 02462, USA.
  • Hollis BW; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  • Fuchs CS; Massachusetts General Hospital, Boston, MA 02114, USA.
  • Ng K; Department of Pediatrics, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Meyerhardt JA; Yale Cancer Center, New Haven, CT 06510, USA.
Cancers (Basel) ; 12(11)2020 Nov 20.
Article en En | MEDLINE | ID: mdl-33233566
Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism through which vitamin D supplementation slows cancer progression and reduces cancer death. In this exploratory analysis of a double-blind, multicenter, randomized phase II clinical trial, 105 patients with advanced or metastatic colorectal cancer who were receiving chemotherapy were randomized to either high-dose vitamin D3 (4000 IU) or standard-dose (400 IU) vitamin D3. Body composition was measured with abdominal computed tomography at enrollment (baseline) and after cycle 8 of chemotherapy (16 weeks). As compared with standard-dose vitamin D3, high-dose vitamin D3 did not significantly change body weight [-0.7 kg; (95% CI: -3.5, 2.0)], body mass index [-0.2 kg/m2; (95% CI: -1.2, 0.7)], muscle area [-1.7 cm2; (95% CI: -9.6, 6.3)], muscle attenuation [-0.4 HU; (95% CI: -4.2, 3.2)], visceral adipose tissue area [-7.5 cm2; (95% CI: -24.5, 9.6)], or subcutaneous adipose tissue area [-8.3 cm2; (95% CI: -35.5, 18.9)] over the first 8 cycles of chemotherapy. Among patients with advanced or metastatic colorectal cancer, the addition of high-dose vitamin D3, vs standard-dose vitamin D3, to standard chemotherapy did not result in any changes in body composition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Cancers (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Cancers (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza