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The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.
Chengyong, Wu; Jinghong, Xian; Yanyan, Wang; Qing-Jie, Xiao; Lingling, Ma; Yuyan, Li; Hai, Chen; Qian, Lei; Quan, Zhang; Bo, Sun; Yuxi, Wang.
Afiliación
  • Chengyong W; Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Jinghong X; Department of Clinical Research, West China Hospital, Sichuan University, Chengdu, China.
  • Yanyan W; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Qing-Jie X; Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Lingling M; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Yuyan L; Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Hai C; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Qian L; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Quan Z; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
  • Bo S; Chinese Academy of Sciences, Shanghai Synchrotron Radiation Facility Science Center, Shanghai Advanced Research Institute, China.
  • Yuxi W; Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
FEBS Lett ; 595(2): 195-205, 2021 01.
Article en En | MEDLINE | ID: mdl-33220079
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Tubulina (Proteína) / Moduladores de Tubulina Idioma: En Revista: FEBS Lett Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Tubulina (Proteína) / Moduladores de Tubulina Idioma: En Revista: FEBS Lett Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido