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Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis.
Moss, Alastair J; Sim, Alisia M; Adamson, Philip D; Seidman, Michael A; Andrews, Jack P M; Doris, Mhairi K; Shah, Anoop S V; BouHaidar, Ralph; Alcaide-Corral, Carlos J; Williams, Michelle C; Leipsic, Jonathon A; Dweck, Marc R; MacRae, Vicky E; Newby, David E; Tavares, Adriana A S; Sellers, Stephanie L.
Afiliación
  • Moss AJ; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. alastairmoss@gmail.com.
  • Sim AM; British Heart Foundation Cardiovascular Research Centre, University of Leicester, Leicester, UK. alastairmoss@gmail.com.
  • Adamson PD; EaStCHEM School of Chemistry, University of Edinburgh, Edinburgh, UK.
  • Seidman MA; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
  • Andrews JPM; Christchurch Heart Institute, University of Otago, Christchurch, New Zealand.
  • Doris MK; Department of Pathology, St Paul's Hospital and University of British Columbia, Vancouver, Canada.
  • Shah ASV; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
  • BouHaidar R; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
  • Alcaide-Corral CJ; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
  • Williams MC; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
  • Leipsic JA; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
  • Dweck MR; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
  • MacRae VE; Department of Radiology and Centre for Heart Lung Innovation, St Paul's Hospital and University of British Columbia, Vancouver, Canada.
  • Newby DE; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
  • Tavares AAS; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
  • Sellers SL; BHF Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
Sci Rep ; 10(1): 20172, 2020 11 19.
Article en En | MEDLINE | ID: mdl-33214599
Early microcalcification is a feature of coronary plaques with an increased propensity to rupture and to cause acute coronary syndromes. In this ex vivo imaging study of coronary artery specimens, the non-invasive imaging radiotracer, 18F-fluoride, was highly selective for hydroxyapatite deposition in atherosclerotic coronary plaque. Specifically, coronary 18F-fluoride uptake had a high signal to noise ratio compared with surrounding myocardium that makes it feasible to identify coronary mineralisation activity. Areas of 18F-fluoride uptake are associated with osteopontin, an inflammation-associated glycophosphoprotein that mediates tissue mineralisation, and Runt-related transcription factor 2, a nuclear protein involved in osteoblastic differentiation. These results suggest that 18F-fluoride is a non-invasive imaging biomarker of active coronary atherosclerotic mineralisation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Radioisótopos de Flúor / Durapatita Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Radioisótopos de Flúor / Durapatita Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido