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First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques.
Kisu, Iori; Kato, Yojiro; Masugi, Yohei; Ishigaki, Hirohito; Yamada, Yohei; Matsubara, Kentaro; Obara, Hideaki; Emoto, Katsura; Matoba, Yusuke; Adachi, Masataka; Banno, Kouji; Saiki, Yoko; Sasamura, Takako; Itagaki, Iori; Kawamoto, Ikuo; Iwatani, Chizuru; Nakagawa, Takahiro; Murase, Mitsuru; Tsuchiya, Hideaki; Urano, Hiroyuki; Ema, Masatsugu; Ogasawara, Kazumasa; Aoki, Daisuke; Nakagawa, Kenshi; Shiina, Takashi.
Afiliación
  • Kisu I; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Kato Y; Department of Surgery, Division of Gastroenterological and General Surgery, School of Medicine, Showa University, Tokyo 1428555, Japan.
  • Masugi Y; Department of Pathology, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Ishigaki H; Department of Pathology, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Yamada Y; Department of Pediatric Surgery, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Matsubara K; Department of Surgery, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Obara H; Department of Surgery, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Emoto K; Department of Pathology, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Matoba Y; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Adachi M; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Banno K; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Saiki Y; Department of Anesthesiology, Saiseikai Kanagawaken Hospital, Kanagawa 2210821, Japan.
  • Sasamura T; Department of Pathology, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Itagaki I; Research Center for Animal Life Science, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Kawamoto I; Research Center for Animal Life Science, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Iwatani C; Research Center for Animal Life Science, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Nakagawa T; Research Center for Animal Life Science, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Murase M; Research Center for Animal Life Science, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Tsuchiya H; Research Center for Animal Life Science, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Urano H; Safety Research Center, Ina Research Inc., Nagano 3994501, Japan.
  • Ema M; Research Center for Animal Life Science, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Ogasawara K; Department of Pathology, Shiga University of Medical Science, Shiga 5202192, Japan.
  • Aoki D; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.
  • Nakagawa K; Safety Research Center, Ina Research Inc., Nagano 3994501, Japan.
  • Shiina T; Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa 2591193, Japan.
J Clin Med ; 9(11)2020 Nov 17.
Article en En | MEDLINE | ID: mdl-33213083
Delivery following uterus transplantation (UTx)-an approach for treating uterine factor infertility-has not been reported in nonhuman primate models. Here, six female major histocompatibility complex (MHC)-defined cynomolgus macaques that underwent allogeneic UTx were evaluated. Antithymocyte globulin and rituximab were administered to induce immunosuppression and a triple maintenance regimen was used. Menstruation resumed in all animals with long-term survival, except one, which was euthanized due to infusion associated adverse reaction to antithymocyte globulin. Donor-specific antibodies (DSA) were detected in cases 2, 4, and 5, while humoral rejection occurred in cases 4 and 5. Post-transplant lymphoproliferative disorder (PTLD) developed in cases 2 and 3. Pregnancy was attempted in cases 1, 2, and 3 but was achieved only in case 2, which had haploidentical donor and recipient MHCs. Pregnancy was achieved in case 2 after recovery from graft rejection coincident with DSA and PTLD. A cesarean section was performed at full-term. This is the first report of a successful livebirth following allogeneic UTx in nonhuman primates, although the delivery was achieved via UTx between a pair carrying haploidentical MHCs. Experimental data from nonhuman primates may provide important scientific knowledge needed to resolve unsolved clinical issues in UTx.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Clin Med Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Clin Med Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza