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The promise of human organoids in the digestive system.
Funata, Masaaki; Nio, Yasunori; Erion, Derek M; Thompson, Wendy L; Takebe, Takanori.
Afiliación
  • Funata M; T-CiRA Discovery, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
  • Nio Y; Takeda-CiRA Joint Program, Fujisawa City, Kanagawa, Japan.
  • Erion DM; T-CiRA Discovery, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
  • Thompson WL; Takeda-CiRA Joint Program, Fujisawa City, Kanagawa, Japan.
  • Takebe T; Gastroenterology Drug Discovery Unit, Takeda Pharmaceutical Company Limited, 35 Landsdowne Street, Cambridge, MA, 02139, USA.
Cell Death Differ ; 28(1): 84-94, 2021 01.
Article en En | MEDLINE | ID: mdl-33204011
The advent of organoid technology has enabled scientists and clinicians to utilize cells from primary tissues or pluripotent stem cells (PSCs) to grow self-organizing tissue systems, thus attaining cellular diversity, spatial organization, and functionality as found within digestive tracts. The development of human gastrointestinal (GI) and hepato-biliary-pancreatic organoids as an in-a-dish model present novel opportunities to study humanistic mechanisms of organogenesis, regeneration and pathogenesis. Herein, we review the recent portfolios of primary tissue-derived and PSC-derived organoids in the digestive systems. We also discuss the promise and challenges in disease modeling and drug development applications for digestive disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organoides / Ingeniería de Tejidos / Técnicas de Cultivo Tridimensional de Células Límite: Humans Idioma: En Revista: Cell Death Differ Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organoides / Ingeniería de Tejidos / Técnicas de Cultivo Tridimensional de Células Límite: Humans Idioma: En Revista: Cell Death Differ Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido