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Ten-year changes in visual acuity at baseline and at 2 years after treatment in a Japanese population with age-related macular degeneration.
Sawada, Tomoko; Yasukawa, Tsutomu; Imaizumi, Hiroko; Matsubara, Hisashi; Kimura, Kazuhiro; Terasaki, Hiroto; Ishikawa, Hiroto; Murakami, Tomoya; Takeuchi, Masaru; Mitamura, Yoshinori; Yamashita, Mariko; Takamura, Yoshihiro; Murata, Toshinori; Kogo, Jiro; Ohji, Masahito.
Afiliación
  • Sawada T; Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan. tsawada@belle.shiga-med.ac.jp.
  • Yasukawa T; Department of Ophthalmology, Nagoya City University, Nagoya, Japan.
  • Imaizumi H; Department of Ophthalmology, Sapporo City General Hospital, Sapporo, Japan.
  • Matsubara H; Department of Ophthalmology, Mie University, Tsu, Japan.
  • Kimura K; Department of Ophthalmology, Yamaguchi University, Ube, Japan.
  • Terasaki H; Department of Ophthalmology, Kagoshima University, Kagoshima, Japan.
  • Ishikawa H; Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan.
  • Murakami T; Department of Ophthalmology, University of Tsukuba, Tsukuba, Japan.
  • Takeuchi M; Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan.
  • Mitamura Y; Department of Ophthalmology, Tokushima University, Tokushima, Japan.
  • Yamashita M; Department of Ophthalmology, Nara Medical University, Kashihara, Japan.
  • Takamura Y; Department of Ophthalmology, University of Fukui, Yoshida-gun, Japan.
  • Murata T; Department of Ophthalmology, Shinshu University, Matsumoto, Japan.
  • Kogo J; Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Ohji M; Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.
Graefes Arch Clin Exp Ophthalmol ; 259(5): 1191-1198, 2021 May.
Article en En | MEDLINE | ID: mdl-33201353
PURPOSE: We investigated 10-year changes in baseline best-corrected visual acuity (BCVA), as well as functional and anatomical changes at 1 and 2 years after initial treatment, in eyes with treatment-naïve neovascular age-related macular degeneration (nAMD). METHODS: This retrospective, multicenter, case series reviewed patients with treatment-naïve nAMD who underwent initial treatment from 2006 to 2015, using photodynamic therapy (PDT), anti-vascular endothelial growth factor (VEGF), or a combination of PDT and anti-VEGF. BCVA and central retinal subfield thickness (CRST), were measured at baseline and at 1 or 2 years of follow-up. RESULTS: In total, 3096 eyes of 3096 patients were included from 14 hospitals. Mean BCVA at baseline became significantly better over the 10-year study period (P < 0.001). BCVA at 1 year significantly improved from baseline in patients who underwent initial treatment from 2009 to 2015 (P = 0.001, 2009; P = 0.004, 2010; P = 0.01, 2011; P < 0.001, 2012-2015). BCVA at 2 years significantly improved from baseline in patients who underwent initial treatment from 2012 to 2015 (P < 0.001, 2012; P < 0.001, 2013-2015). CRST at 1 year decreased significantly from CRST at baseline, each year from 2006 to 2015 (P < 0.001, 2006-2015). CRST at 2 years decreased significantly from CRST at baseline, each year from 2006 to 2015 (P = 0.03, 2006; P < 0.001, 2007-2015). CONCLUSION: Baseline BCVA with treatment-naïve nAMD tended to become better during the study period. BCVA at 1 year improved in the era of anti-VEGF; BCVA at 2 years improved in patients who underwent initial treatment in 2012 or later; and CRST decreased in each year during the study period.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de la Angiogénesis / Degeneración Macular Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Graefes Arch Clin Exp Ophthalmol Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de la Angiogénesis / Degeneración Macular Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Graefes Arch Clin Exp Ophthalmol Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania