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Combined chemotherapy of platinum and fluorouracil promotes T cell-mediated antitumor immunity.
Luo, Yixiao; Pei, Siyu; Xu, Jing; Xiao, Yichuan; Zhu, Xiaodong.
Afiliación
  • Luo Y; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
  • Pei S; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • Xu J; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
  • Xiao Y; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
  • Zhu X; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Acta Biochim Biophys Sin (Shanghai) ; 53(1): 29-35, 2021 Jan 12.
Article en En | MEDLINE | ID: mdl-33201175
The two-drug combined chemotherapy of platinum and fluorouracil has been reported to efficiently kill tumor cells as the first-line treatment for advanced gastric cancer. However, the effect of these drugs on T cells remains unclear. Here, we showed that T cells including CD4+ T cells and CD8+ T cells of the patients with advanced gastric cancer after platinum and fluorouracil chemotherapy exhibited enhanced ex vivo proliferation ability as compared to that before chemotherapy. In addition, platinum and fluorouracil also promoted the differentiation of human T cells into Th1 and Th9 subtypes and cytotoxic T lymphocytes (CTLs) in vitro and in vivo. Accordingly, the combination therapy greatly suppressed tumor growth with increased tumor infiltration of Th1, Th9, and CTL cells in a mouse tumor model. Moreover, in activated T cells, long-term treatment with these two drugs further facilitates T cell activation along with promoted nuclear factor-κB (NF-κB) activation. Our findings demonstrate a previously unidentified function of platinum and fluorouracil combination chemotherapy in promoting T cell-mediated antitumor immunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platino (Metal) / Linfocitos T CD4-Positivos / Protocolos de Quimioterapia Combinada Antineoplásica / Linfocitos T CD8-positivos / Fluorouracilo / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Acta Biochim Biophys Sin (Shanghai) Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platino (Metal) / Linfocitos T CD4-Positivos / Protocolos de Quimioterapia Combinada Antineoplásica / Linfocitos T CD8-positivos / Fluorouracilo / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Acta Biochim Biophys Sin (Shanghai) Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China