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Depression and cognitive function in early multiple sclerosis: Multitasking is more sensitive than traditional assessments.
Glukhovsky, Lisa; Kurz, Daniel; Brandstadter, Rachel; Leavitt, Victoria M; Krieger, Stephen; Fabian, Michelle; Katz Sand, Ilana; Klineova, Sylvia; Riley, Claire S; Lublin, Fred D; Miller, Aaron E; Sumowski, James F.
Afiliación
  • Glukhovsky L; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kurz D; Department of Neurology. Maimonides Medical Center, New York, NY, USA.
  • Brandstadter R; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
  • Leavitt VM; Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Krieger S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Fabian M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Katz Sand I; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Klineova S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Riley CS; Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Lublin FD; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Miller AE; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sumowski JF; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mult Scler ; 27(8): 1276-1283, 2021 07.
Article en En | MEDLINE | ID: mdl-33196404
BACKGROUND: Persons with multiple sclerosis (MS) and depression symptoms report real-world cognitive difficulties that may be missed by laboratory cognitive tests. OBJECTIVE: To examine the relationship of depressive symptoms to cognitive monotasking versus multitasking in early MS. METHOD: Persons with early MS (n = 185; ⩽5 years diagnosed) reported mood, completed monotasking and multitasking cognitive tests, and received high-resolution 3.0 T magnetic resonance imaging (MRI). Partial correlations analyzed associations between mood and cognition, controlling for age, sex, estimated premorbid IQ, T2 lesion volume, and normalized gray matter volume. RESULTS: Depression symptoms were more related to worse cognitive multitasking (-0.353, p < 0.001) than monotasking (r = -0.189, p = 0.011). There was a significant albeit weaker link to cognitive efficiency composite score (r = -0.281, p < 0.001), but not composite memory (r = -0.036, p > 0.50). Findings were replicated with a second depression measure. Multitasking was worse in patients with at least mild depression than both patients with no/minimal depression and healthy controls. Multitasking was not related to mood in healthy controls. CONCLUSIONS: Depression symptoms are linked to cognitive multitasking in early MS; standard monotasking cognitive assessments appear less sensitive to depression-related cognition. Further investigation should determine directionality and mechanisms of this relationship, with the goal of enhancing treatment for cognitive dysfunction and depression in MS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunción Cognitiva / Esclerosis Múltiple Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Humans Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunción Cognitiva / Esclerosis Múltiple Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Humans Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido