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Protective Intranasal Immunization Against Influenza Virus in Infant Mice Is Dependent on IL-6.
Bonney, Elizabeth Ann; Krebs, Kendall; Kim, Jihye; Prakash, Kirtika; Torrance, Blake L; Haynes, Laura; Rincon, Mercedes.
Afiliación
  • Bonney EA; Department of Obstetrics, Gynecology and Reproductive Sciences, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
  • Krebs K; Department of Obstetrics, Gynecology and Reproductive Sciences, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
  • Kim J; Division of Medical Oncology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States.
  • Prakash K; Department of Obstetrics, Gynecology and Reproductive Sciences, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
  • Torrance BL; Department of Immunology, University of Connecticut Center on Aging, Farmington, CT, United States.
  • Haynes L; Department of Immunology, University of Connecticut Center on Aging, Farmington, CT, United States.
  • Rincon M; Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Front Immunol ; 11: 568978, 2020.
Article en En | MEDLINE | ID: mdl-33193346
Respiratory diseases adversely affect infants and are the focus of efforts to develop vaccinations and other modalities to prevent disease. The infant immune system differs from that of older children and adults in many ways that are as yet ill understood. We have used a C57BL/6 mouse model of infection with a laboratory- adapted strain of influenza (PR8) to delineate the importance of the cytokine IL-6 in the innate response to primary infection and in the development of protective immunity in adult mice. Herein, we used this same model in infant (14 days of age) mice to determine the effect of IL-6 deficiency. Infant wild type mice are more susceptible than older mice to infection, similar to the findings in humans. IL-6 is expressed in the lung in the early response to PR8 infection. While intramuscular immunization does not protect against lethal challenge, intranasal administration of heat inactivated virus is protective and correlates with expression of IL-6 in the lung, activation of lung CD8 cells, and development of an influenza-specific antibody response. In IL-6 deficient mice, this response is abrogated, and deficient mice are not protected against lethal challenge. These studies support the importance of the role of the tissue environment in infant immunity, and further suggest that IL-6 may be helpful in the generation of protective immune responses in infants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Influenza A / Interleucina-6 / Inmunización / Infecciones por Orthomyxoviridae / Interacciones Huésped-Patógeno Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Influenza A / Interleucina-6 / Inmunización / Infecciones por Orthomyxoviridae / Interacciones Huésped-Patógeno Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza