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Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action.
Sharifi-Rad, Javad; Kamiloglu, Senem; Yeskaliyeva, Balakyz; Beyatli, Ahmet; Alfred, Mary Angelia; Salehi, Bahare; Calina, Daniela; Docea, Anca Oana; Imran, Muhammad; Anil Kumar, Nanjangud Venaktesh; Romero-Román, Maria Eugenia; Maroyi, Alfred; Martorell, Miquel.
Afiliación
  • Sharifi-Rad J; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Kamiloglu S; Science and Technology Application and Research Center (BITAUM), Bursa Uludag University, Bursa, Turkey.
  • Yeskaliyeva B; Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
  • Beyatli A; Department of Medicinal and Aromatic Plants, University of Health Sciences, Istanbul, Turkey.
  • Alfred MA; Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.
  • Salehi B; Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
  • Docea AO; Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
  • Imran M; Faculty of Allied Health Sciences, University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan.
  • Anil Kumar NV; Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.
  • Romero-Román ME; Laboratorio de Análisis Químico, Departamento de Producción Vegetal, Facultad de Agronomía, Universidad de Concepción, Concepción, Chile.
  • Maroyi A; Department of Botany, University of Fort Hare, Alice, South Africa.
  • Martorell M; Department of Nutrition and Dietetics, Faculty of Pharmacy, Centre for Healthy Living, University of Concepción, Concepción, Chile.
Front Pharmacol ; 11: 571459, 2020.
Article en En | MEDLINE | ID: mdl-33192514
Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling pathways. In this review, we conducted literature research on the PubMed database using the following keywords: "Psoralidin" or "therapeutic effects" or "biological activity" or "Cullen corylifolium" in order to identify relevant studies regarding PSO bioavailability and mechanisms of therapeutic effects in different diseases based on preclinical, experimental studies. In the light of psoralidin beneficial actions for human health, this paper gathers complete information on its pharmacotherapeutic effects and opens new natural therapeutic perspectives in chronic diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Suiza