Your browser doesn't support javascript.
loading
Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults.
Evangelista, Nicole D; O'Shea, Andrew; Kraft, Jessica N; Hausman, Hanna K; Boutzoukas, Emanuel M; Nissim, Nicole R; Albizu, Alejandro; Hardcastle, Cheshire; Van Etten, Emily J; Bharadwaj, Pradyumna K; Smith, Samantha G; Song, Hyun; Hishaw, Georg A; DeKosky, Steven; Wu, Samuel; Porges, Eric; Alexander, Gene E; Marsiske, Michael; Cohen, Ronald; Woods, Adam J.
Afiliación
  • Evangelista ND; Center for Cognitive Aging and Memory Clinical Translational Research, McKnight Brain Institute, University of Florida, Gainesville, FL, 32611, USA.
  • O'Shea A; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, USA.
  • Kraft JN; Center for Cognitive Aging and Memory Clinical Translational Research, McKnight Brain Institute, University of Florida, Gainesville, FL, 32611, USA.
  • Hausman HK; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, USA.
  • Boutzoukas EM; Center for Cognitive Aging and Memory Clinical Translational Research, McKnight Brain Institute, University of Florida, Gainesville, FL, 32611, USA.
  • Nissim NR; Department of Neuroscience, College of Medicine, University of Florida.
  • Albizu A; Center for Cognitive Aging and Memory Clinical Translational Research, McKnight Brain Institute, University of Florida, Gainesville, FL, 32611, USA.
  • Hardcastle C; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, USA.
  • Van Etten EJ; Center for Cognitive Aging and Memory Clinical Translational Research, McKnight Brain Institute, University of Florida, Gainesville, FL, 32611, USA.
  • Bharadwaj PK; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, USA.
  • Smith SG; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Song H; Center for Cognitive Aging and Memory Clinical Translational Research, McKnight Brain Institute, University of Florida, Gainesville, FL, 32611, USA.
  • Hishaw GA; Department of Neuroscience, College of Medicine, University of Florida.
  • DeKosky S; Center for Cognitive Aging and Memory Clinical Translational Research, McKnight Brain Institute, University of Florida, Gainesville, FL, 32611, USA.
  • Wu S; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, USA.
  • Porges E; Department of Psychology and McKnight Brain Institute, University of Arizona, Tucson, AZ, 85721, USA.
  • Alexander GE; Department of Psychology and McKnight Brain Institute, University of Arizona, Tucson, AZ, 85721, USA.
  • Marsiske M; Department of Psychology and McKnight Brain Institute, University of Arizona, Tucson, AZ, 85721, USA.
  • Cohen R; Department of Psychology and McKnight Brain Institute, University of Arizona, Tucson, AZ, 85721, USA.
  • Woods AJ; Department of Psychiatry, Department of Neurology, College of Medicine, University of Arizona, Tucson, AZ, 85721, USA.
Cereb Cortex ; 31(3): 1732-1743, 2021 02 05.
Article en En | MEDLINE | ID: mdl-33188384
Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies have integrated multimodal imaging to simultaneously investigate relationships among structure, function, and cognition. We aimed to clarify how specifically DLPFC structure and function contribute to working memory in healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging and were divided into higher and lower groups based on a median split of in-scanner n-back task performance. Three a priori spherical DLPFC regions of interest (ROIs) were used to quantify blood-oxygen-level-dependent (BOLD) signal and FreeSurfer-derived surface area, cortical thickness, and white matter volume. Binary logistic regressions adjusting for age, sex, education, and scanner type revealed that greater left and right DLPFC BOLD signal predicted the probability of higher performing group membership (P values<.05). Binary logistic regressions also adjusting for total intracranial volume revealed left DLPFC surface area that significantly predicted the probability of being in the higher performing group (P = 0.017). The left DLPFC BOLD signal and surface area were not significantly associated and did not significantly interact to predict group membership (P values>.05). Importantly, this suggests BOLD signal and surface area may independently contribute to working memory performance in healthy older adults.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Prefontal Dorsolateral / Memoria a Corto Plazo Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Prefontal Dorsolateral / Memoria a Corto Plazo Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos