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ppGpp functions as an alarmone in metazoa.
Ito, Doshun; Kawamura, Hinata; Oikawa, Akira; Ihara, Yuta; Shibata, Toshio; Nakamura, Nobuhiro; Asano, Tsunaki; Kawabata, Shun-Ichiro; Suzuki, Takashi; Masuda, Shinji.
Afiliación
  • Ito D; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
  • Kawamura H; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
  • Oikawa A; Faculty of Agriculture, Yamagata University, Tsuruoka, Japan.
  • Ihara Y; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
  • Shibata T; Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.
  • Nakamura N; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
  • Asano T; Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, Japan.
  • Kawabata SI; Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.
  • Suzuki T; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
  • Masuda S; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan. shmasuda@bio.titech.ac.jp.
Commun Biol ; 3(1): 671, 2020 11 13.
Article en En | MEDLINE | ID: mdl-33188280
Guanosine 3',5'-bis(pyrophosphate) (ppGpp) functions as a second messenger in bacteria to adjust their physiology in response to environmental changes. In recent years, the ppGpp-specific hydrolase, metazoan SpoT homolog-1 (Mesh1), was shown to have important roles for growth under nutrient deficiency in Drosophila melanogaster. Curiously, however, ppGpp has never been detected in animal cells, and therefore the physiological relevance of this molecule, if any, in metazoans has not been established. Here, we report the detection of ppGpp in Drosophila and human cells and demonstrate that ppGpp accumulation induces metabolic changes, cell death, and eventually lethality in Drosophila. Our results provide the evidence of the existence and function of the ppGpp-dependent stringent response in animals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Guanosina Tetrafosfato Límite: Animals Idioma: En Revista: Commun Biol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Guanosina Tetrafosfato Límite: Animals Idioma: En Revista: Commun Biol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido