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Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice.
Huang, Jinhao; Lyu, Haiyan; Huo, Kang; Do Prado, Leandro B; Tang, Chaoliang; Wang, Zhanqiang; Li, Qifeng; Wong, Julia; Su, Hua.
Afiliación
  • Huang J; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.
  • Lyu H; Center for Cerebrovascular Research, University of California, San Francisco, CA 94143, USA.
  • Huo K; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.
  • Do Prado LB; Center for Cerebrovascular Research, University of California, San Francisco, CA 94143, USA.
  • Tang C; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.
  • Wang Z; Center for Cerebrovascular Research, University of California, San Francisco, CA 94143, USA.
  • Li Q; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.
  • Wong J; Center for Cerebrovascular Research, University of California, San Francisco, CA 94143, USA.
  • Su H; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.
Int J Mol Sci ; 21(22)2020 Nov 11.
Article en En | MEDLINE | ID: mdl-33187248
BACKGROUND: Tibia fracture (BF) before stroke shortly causes long-term post-stroke memory dysfunction in mice. The mechanism is unclear. We hypothesize that BF enhances neuroinflammation and blood brain barrier (BBB) breakdown in the hippocampus and white matter (WM) damage. METHODS: Mice were assigned to groups: BF, stroke, BF+stroke (BF 6 h before stroke) and sham. BBB integrity was analyzed 3 days after the surgeries and WM injury was analyzed 3 days and 8 weeks after the surgeries. RESULTS: Stroke and BF+stroke groups had more activated microglia/macrophages and lower levels of claudin-5 in the ipsilateral hippocampi than the BF group. BF+stroke group had the highest number microglia/macrophages and the lowest level of claudin-5 among all groups and had fewer pericytes than BF group. Stroke and BF+stroke groups had smaller WM areas in the ipsilateral basal ganglia than the sham group 8 weeks after the injuries. The BF+stroke group also had smaller WM areas in the ipsilateral than sham and BF groups 3 days after the injuries and in the contralateral basal ganglia than stroke and BF groups 8 weeks after the injuries. CONCLUSIONS: BF exacerbates neuroinflammation and BBB leakage in the hippocampus and WM damage in basal ganglia, which could contribute to the long-lasting memory dysfunction in BF+stroke mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / Accidente Cerebrovascular / Fracturas Óseas / Sustancia Blanca / Hipocampo Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / Accidente Cerebrovascular / Fracturas Óseas / Sustancia Blanca / Hipocampo Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza