A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent ß-cell apoptosis.

Ahn, Miwon; Oh, Eunjin; McCown, Erika M; Wang, Xin; Veluthakal, Rajakrishnan; Thurmond, Debbie C

Ahn, Miwon; Oh, Eunjin; McCown, Erika M; Wang, Xin; Veluthakal, Rajakrishnan; Thurmond, Debbie C.

Afiliación

Ahn M; Department of Molecular and Cellular Endocrinology, Diabetes and Metabolism Research Institute and Beckman Research Institute at the City of Hope, Duarte, CA 91010, United States of America.
Oh E; Department of Molecular and Cellular Endocrinology, Diabetes and Metabolism Research Institute and Beckman Research Institute at the City of Hope, Duarte, CA 91010, United States of America.
McCown EM; Department of Molecular and Cellular Endocrinology, Diabetes and Metabolism Research Institute and Beckman Research Institute at the City of Hope, Duarte, CA 91010, United States of America.
Wang X; Faculty of Biology, Medicine and Health, University of Manchester, UK.
Veluthakal R; Department of Molecular and Cellular Endocrinology, Diabetes and Metabolism Research Institute and Beckman Research Institute at the City of Hope, Duarte, CA 91010, United States of America.
Thurmond DC; Department of Molecular and Cellular Endocrinology, Diabetes and Metabolism Research Institute and Beckman Research Institute at the City of Hope, Duarte, CA 91010, United States of America. Electronic address: dthurmond@coh.org.

Metabolism ; 115: 154431, 2021 02.

Article en En | MEDLINE | ID: mdl-33181191

Asunto(s)

Apoptosis/fisiología; Diabetes Mellitus Tipo 2/metabolismo; Proteínas del Complejo de Cadena de Transporte de Electrón/metabolismo; Células Secretoras de Insulina/metabolismo; Mitocondrias/metabolismo; Quinasas p21 Activadas/metabolismo; Animales; Intolerancia a la Glucosa/genética; Intolerancia a la Glucosa/metabolismo; Humanos; Resistencia a la Insulina/fisiología; Secreción de Insulina/fisiología; Ratones; Ratones Noqueados; Oxidación-Reducción; Quinasas p21 Activadas/genética

Palabras clave

Diabetes; Electron transport chain; Mitochondrial number; Redox imbalance; ß-Cell mass

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Proteínas del Complejo de Cadena de Transporte de Electrón / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Quinasas p21 Activadas / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Metabolism Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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