Your browser doesn't support javascript.
loading
Effects of Cerebrolysin on Hippocampal Neuronal Death After Pilocarpine-Induced Seizure.
Kang, Dong Hyeon; Choi, Bo Young; Lee, Song Hee; Kho, A Ra; Jeong, Jeong Hyun; Hong, Dae Ki; Kang, Beom Seok; Park, Min Kyu; Song, Hong Ki; Choi, Hui Chul; Lim, Man-Sup; Suh, Sang Won.
Afiliación
  • Kang DH; Department of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Choi BY; Neurology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Lee SH; Department of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Kho AR; Department of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Jeong JH; Department of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Hong DK; Department of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Kang BS; Department of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Park MK; Department of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Song HK; Department of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Choi HC; Neurology, College of Medicine, Hallym University, Chuncheon, South Korea.
  • Lim MS; Hallym Institute of Epilepsy Research, Chuncheon, South Korea.
  • Suh SW; Neurology, College of Medicine, Hallym University, Chuncheon, South Korea.
Front Neurosci ; 14: 568813, 2020.
Article en En | MEDLINE | ID: mdl-33177978
Epilepsy is one of the most common and severe brain diseases. The exact cause of epilepsy is unclear. Epilepsy often occurs following brain damage, such as traumatic brain injury (TBI) and ischemia. Cerebrolysin is a porcine brain peptide that is a unique neurotropic and neuroprotective agent. Cerebrolysin has been reported to increase neuroprotective effects after TBI, ischemia, and other CNS diseases. However, the effects of cerebrolysin on seizures are not known. Therefore, this study aimed to investigate the effects of neuropeptide cerebrolysin on neuronal death in the hippocampus after a seizure. To confirm the effects of cerebrolysin, we used a pilocarpine-induced seizure animal model. Cerebrolysin (2.5 ml/kg, i.p., once per day for 7 days) was immediately injected after a seizure induction. After 1 week, we obtained brain tissues and performed staining to histologically evaluate the potentially protective effects of cerebrolysin on seizure-induced neuronal death in the hippocampus. We found that cerebrolysin decreased hippocampal neuronal death after a seizure. In addition, an increase in brain-derived neurotrophic factor (BDNF) was confirmed through Western blot analysis to further support our hypothesis. Therefore, the present study suggests that the administration of cerebrolysin can be a useful therapeutic tool for preventing neuronal death after a seizure.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Neurosci Año: 2020 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Neurosci Año: 2020 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Suiza