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Pulmonary toxicity of synthetic amorphous silica - effects of porosity and copper oxide doping.
Hadrup, Niels; Aimonen, Kukka; Ilves, Marit; Lindberg, Hanna; Atluri, Rambabu; Sahlgren, Nicklas M; Jacobsen, Nicklas R; Barfod, Kenneth K; Berthing, Trine; Lawlor, Alan; Norppa, Hannu; Wolff, Henrik; Jensen, Keld A; Hougaard, Karin S; Alenius, Harri; Catalan, Julia; Vogel, Ulla.
Afiliación
  • Hadrup N; National Research Centre for the Working Environment (NFA), Copenhagen, Denmark.
  • Aimonen K; Finnish Institute of Occupational Health (FIOH), Helsinki, Finland.
  • Ilves M; Human Microbiome Research Program, University of Helsinki, Helsinki, Finland.
  • Lindberg H; Finnish Institute of Occupational Health (FIOH), Helsinki, Finland.
  • Atluri R; National Research Centre for the Working Environment (NFA), Copenhagen, Denmark.
  • Sahlgren NM; National Research Centre for the Working Environment (NFA), Copenhagen, Denmark.
  • Jacobsen NR; National Research Centre for the Working Environment (NFA), Copenhagen, Denmark.
  • Barfod KK; National Research Centre for the Working Environment (NFA), Copenhagen, Denmark.
  • Berthing T; Department of Veterinary and Animal Sciences. Experimental Animal Models, University of Copenhagen, Denmark.
  • Lawlor A; National Research Centre for the Working Environment (NFA), Copenhagen, Denmark.
  • Norppa H; CEH Lancaster, Lancaster Environment Centre, Lancaster, UK.
  • Wolff H; Finnish Institute of Occupational Health (FIOH), Helsinki, Finland.
  • Jensen KA; Finnish Institute of Occupational Health (FIOH), Helsinki, Finland.
  • Hougaard KS; National Research Centre for the Working Environment (NFA), Copenhagen, Denmark.
  • Alenius H; National Research Centre for the Working Environment (NFA), Copenhagen, Denmark.
  • Catalan J; Institute of Public Health, University of Copenhagen, Copenhagen, Denmark.
  • Vogel U; Human Microbiome Research Program, University of Helsinki, Helsinki, Finland.
Nanotoxicology ; 15(1): 96-113, 2021 02.
Article en En | MEDLINE | ID: mdl-33176111
Materials can be modified for improved functionality. Our aim was to test whether pulmonary toxicity of silica nanomaterials is increased by the introduction of: a) porosity; and b) surface doping with CuO; and whether c) these modifications act synergistically. Mice were exposed by intratracheal instillation and for some doses also oropharyngeal aspiration to: 1) solid silica 100 nm; 2) porous silica 100 nm; 3) porous silica 100 nm with CuO doping; 4) solid silica 300 nm; 5) porous silica 300 nm; 6) solid silica 300 nm with CuO doping; 7) porous silica 300 nm with CuO doping; 8) CuO nanoparticles 9.8 nm; or 9) carbon black Printex 90 as benchmark. Based on a pilot study, dose levels were between 0.5 and 162 µg/mouse (0.2 and 8.1 mg/kg bw). Endpoints included pulmonary inflammation (neutrophil numbers in bronchoalveolar fluid), acute phase response, histopathology, and genotoxicity assessed by the comet assay, micronucleus test, and the gamma-H2AX assay. The porous silica materials induced greater pulmonary inflammation than their solid counterparts. A similar pattern was seen for acute phase response induction and histologic changes. This could be explained by a higher specific surface area per mass unit for the most toxic particles. CuO doping further increased the acute phase response normalized according to the deposited surface area. We identified no consistent evidence of synergism between surface area and CuO doping. In conclusion, porosity and CuO doping each increased the toxicity of silica nanomaterials and there was no indication of synergy when the modifications co-occurred.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Dióxido de Silicio / Cobre / Nanopartículas Límite: Animals Idioma: En Revista: Nanotoxicology Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Dióxido de Silicio / Cobre / Nanopartículas Límite: Animals Idioma: En Revista: Nanotoxicology Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido