Your browser doesn't support javascript.
loading
Pregnancy complicated by refractory severe hypercholanaemia from sodium taurocholate co-transporting polypeptide deficiency.
Wu, Christine; Smet, Maria-Elisabeth; Heath, Susan; Curnow, Jennifer; Lin, Ming-Wei; George, Jacob; Alahakoon, Thushari I.
Afiliación
  • Wu C; Westmead Institute for Maternal and Fetal Medicine, Westmead Hospital, Sydney, New South Wales, Australia.
  • Smet ME; Westmead Institute for Maternal and Fetal Medicine, Westmead Hospital, Sydney, New South Wales, Australia.
  • Heath S; Sydney Ultrasound for Women, Chatswood, New South Wales, Australia.
  • Curnow J; Westmead Institute for Maternal and Fetal Medicine, Westmead Hospital, Sydney, New South Wales, Australia.
  • Lin MW; Department of Haematology, Westmead Hospital, Sydney, New South Wales, Australia.
  • George J; Department of Immunology, Westmead Hospital, Sydney, New South Wales, Australia.
  • Alahakoon TI; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
J Obstet Gynaecol Res ; 47(2): 822-826, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33174277
Sodium taurocholate co-transporting polypeptide deficiency is a rare metabolic autosomal recessive condition resulting in critically elevated plasma bile acid levels. Hypercholanaemia in similar conditions such as intrahepatic cholestasis of pregnancy has been associated with an increased risk of adverse obstetric outcomes including stillbirth. We present the first case of Sodium taurocholate co-transporting polypeptide deficiency in a current pregnancy in a patient with one previous stillbirth in the context of severe hypercholanaemia, where conventional treatments for cholestasis including ursodeoxycholic acid, rifampicin and cholestyramine were ineffective. Therapeutic plasma exchange and novel treatment with elobixibat were trialed with mixed results. The pregnancy resulted in an iatrogenic preterm delivery of a live infant at 32 weeks gestation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Colestasis Intrahepática Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Colestasis Intrahepática Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia