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A novel technique to produce tubular scaffolds based on collagen and elastin.
Rodrigues, Isabella C P; Pereira, Karina D; Woigt, Luiza F; Jardini, André L; Luchessi, Augusto D; Lopes, Éder S N; Webster, Thomas J; Gabriel, Laís P.
Afiliación
  • Rodrigues ICP; School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • Pereira KD; School of Mechanical Engineering, University of Campinas, Campinas, Brazil.
  • Woigt LF; School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • Jardini AL; Institute of Biosciences, São Paulo State University, Rio Claro, Brazil.
  • Luchessi AD; School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • Lopes ÉSN; National Institute of Biofabrication, Campinas, Brazil.
  • Webster TJ; School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • Gabriel LP; Institute of Biosciences, São Paulo State University, Rio Claro, Brazil.
Artif Organs ; 45(5): E113-E122, 2021 May.
Article en En | MEDLINE | ID: mdl-33169400
Tubular polymer scaffolds based on tissue engineering techniques have been studied as potential alternatives for vascular regeneration implants. The blood vessels of the cardiovascular system are mainly fibrous, composed of collagen (Col) and elastin (El), and its inner layer consists of endothelial cells. In this work, Col and El were combined with polyurethane (PU), a biocompatible synthetic polymer, and rotary jet spinning, a new and highly productive technique, to produce fibrous scaffolds. The scaffolds produced at 18 000 rpm presented homogeneous, bead-free, and solvent-free fibers. The blend formation between PU-Col-El was identified by chemical composition analysis and enhanced the thermal stability up to 324°C. The hydrophilic nature of the scaffold was revealed by its low contact angle. Cell viability of human umbilical vein endothelial cells with the scaffold was proven for 72 hours. The combined strategy of rotary jet spinning with a polymer blend containing Col and El was verified as an effective and promising alternative to obtain tubular scaffolds for tissue engineering on a large-scale production.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Prótesis Vascular / Ingeniería de Tejidos / Andamios del Tejido Límite: Humans Idioma: En Revista: Artif Organs Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Prótesis Vascular / Ingeniería de Tejidos / Andamios del Tejido Límite: Humans Idioma: En Revista: Artif Organs Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos