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Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry.
Núñez-Gil, Iván J; Fernández-Pérez, Cristina; Estrada, Vicente; Becerra-Muñoz, Víctor M; El-Battrawy, Ibrahim; Uribarri, Aitor; Fernández-Rozas, Inmaculada; Feltes, Gisela; Viana-Llamas, María C; Trabattoni, Daniela; López-País, Javier; Pepe, Martino; Romero, Rodolfo; Castro-Mejía, Alex F; Cerrato, Enrico; Astrua, Thamar Capel; D'Ascenzo, Fabrizio; Fabregat-Andres, Oscar; Moreu, José; Guerra, Federico; Signes-Costa, Jaime; Marín, Francisco; Buosenso, Danilo; Bardají, Alfredo; Raposeiras-Roubín, Sergio; Elola, Javier; Molino, Ángel; Gómez-Doblas, Juan J; Abumayyaleh, Mohammad; Aparisi, Álvaro; Molina, María; Guerri, Asunción; Arroyo-Espliguero, Ramón; Assanelli, Emilio; Mapelli, Massimo; García-Acuña, José M; Brindicci, Gaetano; Manzone, Edoardo; Ortega-Armas, María E; Bianco, Matteo; Trung, Chinh Pham; Núñez, María José; Castellanos-Lluch, Carmen; García-Vázquez, Elisa; Cabello-Clotet, Noemí; Jamhour-Chelh, Karim; Tellez, María J; Fernández-Ortiz, Antonio; Macaya, Carlos.
Afiliación
  • Núñez-Gil IJ; Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain. ibnsky@yahoo.es.
  • Fernández-Pérez C; Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
  • Estrada V; Fundación Instituto para la Mejora de la Asistencia Sanitaria (IMAS), Madrid, Spain.
  • Becerra-Muñoz VM; Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.
  • El-Battrawy I; Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de La Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.
  • Uribarri A; University Mannheim, Mannheim, Germany.
  • Fernández-Rozas I; Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
  • Feltes G; Hospital Severo Ochoa, Leganés, Spain.
  • Viana-Llamas MC; Hospital Nuestra Señora de América, Madrid, Spain.
  • Trabattoni D; Hospital Universitario Guadalajara, Guadalajara, Spain.
  • López-País J; Centro Cardiologico Monzino, IRCCS, Milan, Italy.
  • Pepe M; Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
  • Romero R; Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Bari, Italy.
  • Castro-Mejía AF; Hospital Universitario Getafe, Madrid, Spain.
  • Cerrato E; Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.
  • Astrua TC; Cardiology Division, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
  • D'Ascenzo F; Rivoli Infermi Hospital, Rivoli, Turin, Italy.
  • Fabregat-Andres O; Hospital Virgen del Mar, Madrid, Spain.
  • Moreu J; San Giovanni Battista, Turin, Italy.
  • Guerra F; Hospital IMED, Valencia, Spain.
  • Signes-Costa J; Complejo hospitalario de Toledo, Toledo, Spain.
  • Marín F; Cardiology and Arrhythmology Clinic, Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy.
  • Buosenso D; Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.
  • Bardají A; Hospital Clinico Universitario Virgen de la Arreixaca, Murcia, Spain.
  • Raposeiras-Roubín S; IMIB-Arreixaca, Universidad de Murcia, Murcia, Spain.
  • Elola J; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Molino Á; University Hospital Joan XXIII, Tarragona, Spain.
  • Gómez-Doblas JJ; University Hospital Álvaro Cunqueiro, Vigo, Spain.
  • Abumayyaleh M; Fundación Instituto para la Mejora de la Asistencia Sanitaria (IMAS), Madrid, Spain.
  • Aparisi Á; Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.
  • Molina M; Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de La Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.
  • Guerri A; University Mannheim, Mannheim, Germany.
  • Arroyo-Espliguero R; Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
  • Assanelli E; Hospital Severo Ochoa, Leganés, Spain.
  • Mapelli M; Hospital Nuestra Señora de América, Madrid, Spain.
  • García-Acuña JM; Hospital Universitario Guadalajara, Guadalajara, Spain.
  • Brindicci G; Centro Cardiologico Monzino, IRCCS, Milan, Italy.
  • Manzone E; Centro Cardiologico Monzino, IRCCS, Milan, Italy.
  • Ortega-Armas ME; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.
  • Bianco M; Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
  • Trung CP; Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Bari, Italy.
  • Núñez MJ; Hospital Universitario Getafe, Madrid, Spain.
  • Castellanos-Lluch C; Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.
  • García-Vázquez E; Cardiology Division, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
  • Cabello-Clotet N; Hospital Virgen del Mar, Madrid, Spain.
  • Jamhour-Chelh K; Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.
  • Tellez MJ; Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.
  • Fernández-Ortiz A; Hospital Clinico Universitario Virgen de la Arreixaca, Murcia, Spain.
  • Macaya C; IMIB-Arreixaca, Universidad de Murcia, Murcia, Spain.
Intern Emerg Med ; 16(4): 957-966, 2021 06.
Article en En | MEDLINE | ID: mdl-33165755
Recently the coronavirus disease (COVID-19) outbreak has been declared a pandemic. Despite its aggressive extension and significant morbidity and mortality, risk factors are poorly characterized outside China. We designed a registry, HOPE COVID-19 (NCT04334291), assessing data of 1021 patients discharged (dead or alive) after COVID-19, from 23 hospitals in 4 countries, between 8 February and 1 April. The primary end-point was all-cause mortality aiming to produce a mortality risk score calculator. The median age was 68 years (IQR 52-79), and 59.5% were male. Most frequent comorbidities were hypertension (46.8%) and dyslipidemia (35.8%). A relevant heart or lung disease were depicted in 20%. And renal, neurological, or oncological disease, respectively, were detected in nearly 10%. Most common symptoms were fever, cough, and dyspnea at admission. 311 patients died and 710 were discharged alive. In the death-multivariate analysis, raised as most relevant: age, hypertension, obesity, renal insufficiency, any immunosuppressive disease, 02 saturation < 92% and an elevated C reactive protein (AUC = 0.87; Hosmer-Lemeshow test, p > 0.999; bootstrap-optimist: 0.0018). We provide a simple clinical score to estimate probability of death, dividing patients in four grades (I-IV) of increasing probability. Hydroxychloroquine (79.2%) and antivirals (67.6%) were the specific drugs most commonly used. After a propensity score adjustment, the results suggested a slight improvement in mortality rates (adjusted-ORhydroxychloroquine 0.88; 95% CI 0.81-0.91, p = 0.005; adjusted-ORantiviral 0.94; 95% CI 0.87-1.01; p = 0.115). COVID-19 produces important mortality, mostly in patients with comorbidities with respiratory symptoms. Hydroxychloroquine could be associated with survival benefit, but this data need to be confirmed with further trials. Trial Registration: NCT04334291/EUPAS34399.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Intern Emerg Med Asunto de la revista: MEDICINA DE EMERGENCIA / MEDICINA INTERNA Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Intern Emerg Med Asunto de la revista: MEDICINA DE EMERGENCIA / MEDICINA INTERNA Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia