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The Gut Mycobiome in Parkinson's Disease.
Cirstea, Mihai S; Sundvick, Kristen; Golz, Ella; Yu, Adam C; Boutin, Rozlyn C T; Kliger, Daniel; Finlay, Brett B; Appel-Cresswell, Silke.
Afiliación
  • Cirstea MS; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Sundvick K; Michael Smith Laboratories, UBC, Vancouver, British Columbia, Canada.
  • Golz E; Pacific Parkinson's Research Centre and Djavad Mowafaghian Centre for Brain Health, UBC, Vancouver, British Columbia, Canada.
  • Yu AC; Pacific Parkinson's Research Centre and Djavad Mowafaghian Centre for Brain Health, UBC, Vancouver, British Columbia, Canada.
  • Boutin RCT; Pacific Parkinson's Research Centre and Djavad Mowafaghian Centre for Brain Health, UBC, Vancouver, British Columbia, Canada.
  • Kliger D; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Finlay BB; Michael Smith Laboratories, UBC, Vancouver, British Columbia, Canada.
  • Appel-Cresswell S; Pacific Parkinson's Research Centre and Djavad Mowafaghian Centre for Brain Health, UBC, Vancouver, British Columbia, Canada.
J Parkinsons Dis ; 11(1): 153-158, 2021.
Article en En | MEDLINE | ID: mdl-33164944
The gut microbiome has been increasingly implicated in Parkinson's disease (PD); however, most existing studies employ bacterial-specific sequencing, and have not investigated non-bacterial microbiome constituents. Here, we use fungal-specific internal transcribed spacer (ITS)-2 amplicon sequencing in a cross-sectional PD cohort to investigate associations between the fungal gut microbiome and PD. Fungal load among participants was extremely low, and genera identified were almost exclusively of proposed dietary or environmental origin. We observed significantly lower fungal DNA relative to bacterial DNA among PD patients. No fungi differed in abundance between patients and controls, nor were any associated with motor, cognitive, or gastrointestinal features among patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / ADN Bacteriano / ADN de Hongos / Microbioma Gastrointestinal / Micobioma Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Parkinsons Dis Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / ADN Bacteriano / ADN de Hongos / Microbioma Gastrointestinal / Micobioma Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Parkinsons Dis Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos