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Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C.
Bauer, Lisa; Manganaro, Roberto; Zonsics, Birgit; Hurdiss, Daniel L; Zwaagstra, Marleen; Donselaar, Tim; Welter, Naemi G E; van Kleef, Regina G D M; Lopez, Moira Lorenzo; Bevilacqua, Federica; Raman, Thamidur; Ferla, Salvatore; Bassetto, Marcella; Neyts, Johan; Strating, Jeroen R P M; Westerink, Remco H S; Brancale, Andrea; van Kuppeveld, Frank J M.
Afiliación
  • Bauer L; Virology Section, Infectious Disease and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Manganaro R; Medicinal Chemistry, School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
  • Zonsics B; Medicinal Chemistry, School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
  • Hurdiss DL; Virology Section, Infectious Disease and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Zwaagstra M; Virology Section, Infectious Disease and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Donselaar T; Virology Section, Infectious Disease and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Welter NGE; Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • van Kleef RGDM; Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Lopez ML; Medicinal Chemistry, School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
  • Bevilacqua F; Medicinal Chemistry, School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
  • Raman T; Medicinal Chemistry, School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
  • Ferla S; Medicinal Chemistry, School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
  • Bassetto M; Department of Chemistry, Swansea University, Swansea, United Kingdom.
  • Neyts J; Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
  • Strating JRPM; Virology Section, Infectious Disease and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Westerink RHS; Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Brancale A; Medicinal Chemistry, School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
  • van Kuppeveld FJM; Virology Section, Infectious Disease and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
PLoS Biol ; 18(11): e3000904, 2020 11.
Article en En | MEDLINE | ID: mdl-33156822
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Proteínas Portadoras / Proteínas no Estructurales Virales / Enterovirus Límite: Humans Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Proteínas Portadoras / Proteínas no Estructurales Virales / Enterovirus Límite: Humans Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos