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Vitamin D and subclinical cardiac damage in a cohort of kidney transplanted patients: a retrospective observational study.
Alfieri, C; Vettoretti, S; Ruzhytska, O; Gandolfo, M T; Cresseri, D; Campise, M; Caldiroli, L; Favi, E; Binda, V; Messa, P.
Afiliación
  • Alfieri C; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico - Milano, Via Commenda 15, 20122, Milan, Italy.
  • Vettoretti S; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
  • Ruzhytska O; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico - Milano, Via Commenda 15, 20122, Milan, Italy.
  • Gandolfo MT; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico - Milano, Via Commenda 15, 20122, Milan, Italy.
  • Cresseri D; Department of Internal Medicine n3, Ternopil National Medical University, Ternopil, Ukraine.
  • Campise M; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico - Milano, Via Commenda 15, 20122, Milan, Italy.
  • Caldiroli L; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico - Milano, Via Commenda 15, 20122, Milan, Italy.
  • Favi E; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico - Milano, Via Commenda 15, 20122, Milan, Italy.
  • Binda V; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico - Milano, Via Commenda 15, 20122, Milan, Italy.
  • Messa P; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Sci Rep ; 10(1): 19160, 2020 11 05.
Article en En | MEDLINE | ID: mdl-33154468
In 178-kidney transplanted patients (KTxp), the prevalence of hypovitaminosis-D, the presence and novel development of left ventricular hypertrophy(LVH) and the correlations between native Vitamin-D (25OHD) and LVH were evaluated during the 1st year of transplantation (KTx). Clinical and instrumental data were recorded at pre-KTx and at one (T1) and 12 (T12) months after KTx. 25OHD levels were considered sufficient (s25OHD, ≥ 30 ng/dL) or insufficient (i25OHD, < 30 ng/dL). 25OHD correlated at T1 with parathormone(PTH), and at T12 with 25OHD-T1 and PTH-(T1,T12). At T12, s25OHD (15%) had higher 25OH and alkaline phosphatase (ALP), lower Ca, at T1, and lower PTH-(T1, T12) than i25OH-T12. At T1, KTxp with LVH (LVH-T1pos, 42%) were older and with longer dialysis vintage than LVH-T1neg. At T12, KTxp with LVH (LVH-T12pos, 53%) were older, with higher systolic blood pressure (SBP) at T12 than LVH-T12neg. No relation between 25OHD and LVH were found. Novel LVH was found in 14% of KTxp. They were older, had higher SBP-T12 and lower serum albumin-T12 than the others. LVH-modifications and 25OHD were not correlated. Hypovitaminosis-D is highly prevalent in KTxp. LVH correlates with different risk factors according to the time elapsed from KTx. However, during the 1st year of KTx, no relationship between LVH and 25OHD was observed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina D / Deficiencia de Vitamina D / Trasplante de Riñón / Hipertrofia Ventricular Izquierda / Receptores de Trasplantes Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina D / Deficiencia de Vitamina D / Trasplante de Riñón / Hipertrofia Ventricular Izquierda / Receptores de Trasplantes Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido