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Clinical and gated SPECT MPI parameters associated with super-response to cardiac resynchronization therapy.
Mesquita, Claudio T; Peix, Amalia; de Amorim Fernandes, Fernando; Giubbini, Raffaele; Karthikeyan, Ganesan; Massardo, Teresa; Patel, Chetan; Pabon, Luz M; Jimenez-Heffernan, Amelia; Alexanderson, Erick; Butt, Sadaf; Kumar, Alka; Marin, Victor; Morozova, Olga; Paez, Diana; Garcia, Ernest V.
Afiliación
  • Mesquita CT; Hospital Universitario Antonio Pedro-Ebeserh UFF, Niteroi, 24033-900, Brazil. claudiotinocomesquita@id.uff.br.
  • Peix A; Nuclear Medicine Department, Institute of Cardiology, La Habana, Cuba.
  • de Amorim Fernandes F; Hospital Universitario Antonio Pedro-Ebeserh UFF, Niteroi, 24033-900, Brazil.
  • Giubbini R; Nuclear Medicine, Spedali Civili, Brescia, Italy.
  • Karthikeyan G; All India Institute of Medical Sciences, New Delhi, India.
  • Massardo T; Hospital Clinico Universidad de Chile, Santiago, Chile.
  • Patel C; All India Institute of Medical Sciences, New Delhi, India.
  • Pabon LM; Fundacion Valle del Lili, Cali, Colombia.
  • Jimenez-Heffernan A; Hospital Juan Ramon Jimenez, Huelva, Spain.
  • Alexanderson E; Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, DF, Mexico.
  • Butt S; Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan.
  • Kumar A; Dr. B L Kapur Memorial Hospital, New Delhi, India.
  • Marin V; Fundacion Cardioinfantil, Bogota, Colombia.
  • Morozova O; Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy Agency, Vienna, Austria.
  • Paez D; Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy Agency, Vienna, Austria.
  • Garcia EV; Emory University, Atlanta, GA, USA.
J Nucl Cardiol ; 29(3): 1166-1174, 2022 06.
Article en En | MEDLINE | ID: mdl-33152098
PURPOSE: We sought to evaluate the behavior of cardiac mechanical synchrony as measured by phase SD (PSD) derived from gated MPI SPECT (gSPECT) in patients with super-response after CRT and to evaluate the clinical and imaging characteristics associated with super-response. METHODS: 158 subjects were evaluated with gSPECT before and 6 months after CRT. Patients with an improvement of LVEF > 15% and NYHA class I/II or reduction in LV end-systolic volume > 30% and NYHA class I/II were labeled as super-responders (SR). RESULTS: 34 patients were classified as super-responders (22%) and had lower PSD (32° ± 17°) at 6 months after CRT compared to responders (45° ± 24°) and non-responders 46° ± 28° (P = .02 for both comparisons). Regression analysis identified predictors independently associated with super-response to CRT: absence of previous history of CAD (odds ratio 18.7; P = .002), absence of diabetes mellitus (odds ratio 13; P = .03), and history of hypertension (odds ratio .2; P = .01). CONCLUSION: LV dyssynchrony after CRT implantation, but not at baseline, was significantly better among super-responders compared to non-super-responders. The absence of diabetes, absence of CAD, and history of hypertension were independently associated with super-response after CRT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia de Resincronización Cardíaca / Insuficiencia Cardíaca / Hipertensión Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia de Resincronización Cardíaca / Insuficiencia Cardíaca / Hipertensión Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos