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Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat.
Schmitt, Maximilian V; Reichel, Andreas; Liu, Xiaohui; Fricker, Gert; Lienau, Philip.
Afiliación
  • Schmitt MV; Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S
  • Reichel A; Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S
  • Liu X; Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S
  • Fricker G; Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S
  • Lienau P; Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S
Drug Metab Dispos ; 49(1): 53-61, 2021 01.
Article en En | MEDLINE | ID: mdl-33148688
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Distribución Tisular / Desarrollo de Medicamentos / Lisosomas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Distribución Tisular / Desarrollo de Medicamentos / Lisosomas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos