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Early Diagnostic Biomarkers of Sepsis for Patients with Acute-on-Chronic Liver Failure: A Multicenter Study.
Chen, Jun; Huang, Ze-Bing; Li, Hai; Zheng, Xin; Chen, Jin-Jun; Wang, Xian-Bo; Qian, Zhi-Ping; Liu, Xiao-Xiao; Fan, Xue-Gong; Hu, Xing-Wang; Liao, Cheng-Jin; Long, Li-Yuan; Huang, Yan.
Afiliación
  • Chen J; Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China.
  • Huang ZB; Key Laboratory of Viral Hepatitis, Hunan, China.
  • Li H; Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China.
  • Zheng X; Key Laboratory of Viral Hepatitis, Hunan, China.
  • Chen JJ; Department of Gastroenterology, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Wang XB; Institute of Digestive Disease, Key Laboratory of Gastroenterology and Hepatology, Chinese Ministry of Health, Shanghai Jiao Tong University, Shanghai, China.
  • Qian ZP; Department of Infectious Diseases, Institute of Infection and Immunology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Hubei, China.
  • Liu XX; Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Fan XG; Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Hu XW; Department of Liver Intensive Care Unit, Shanghai Public Health Clinical Centre, Fudan University, Shanghai, China.
  • Liao CJ; Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China.
  • Long LY; Key Laboratory of Viral Hepatitis, Hunan, China.
  • Huang Y; Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China.
Infect Dis Ther ; 10(1): 281-290, 2021 Mar.
Article en En | MEDLINE | ID: mdl-33146854
INTRODUCTION: Sepsis is a complication in acute-on-chronic liver failure (ACLF) patients associated with high rates of mortality and morbidity. Early diagnosis of sepsis in ACLF patients can improve prognosis. This study aimed to explore potential effective biomarkers for the early diagnosis of sepsis in ACLF patients. METHODS: Ninety-four ACLF patients with sepsis were enrolled from 10 hospitals across China from January 2015 to June 2016 as well as 49 ACLF patients without infection from Xiangya Hospital. The first-day admission data and SOFA score and CLIF-SOFA score were collected. The differences of indicators between groups were compared with Kruskal-Wallis test. The receiver-operating characteristic (ROC) curve was analyzed to evaluate the diagnostic efficiency of the selected factors. RESULTS: Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) and presepsin were significantly higher in ACLF-sepsis patients compared with ACLF patients with no infection (P < 0.001). sTREM-1 and presepsin presented higher diagnostic value in sepsis for ACLF patients compared with other biomarkers [white blood cells (WBC), procalcitonin (PCT) and C-reactive protein (CRP)]. Combining sTREM-1 or presepsin with the CLIF-SOFA score increased the diagnostic efficiency (AUC = 0.876 or AUC = 0.913, respectively). CONCLUSIONS: sTREM-1 and presepsin are potential biomarkers for the early diagnosis of sepsis in ACLF patients. The combination of presepsin and the CLIF-SOFA score is a promising method for diagnosing sepsis in ACLF patients. TRIAL REGISTRATION: ClinicalTrials.gov identifier, NCT02457637.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Infect Dis Ther Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Infect Dis Ther Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Nueva Zelanda