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Co-implantation of Tumor and Extensive Surrounding Tissue Improved the Establishment Rate of Surgical Specimens of Human-Patient Cancer in Nude Mice: Toward the Goal of Universal Individualized Cancer Therapy.
Murata, Takuya; Hozumi, Chihiro; Hiroshima, Yukihiko; Shimoya, Koichiro; Hongo, Atsushi; Inubushi, Sachiko; Tanino, Hirokazu; Hoffman, Robert M.
Afiliación
  • Murata T; Department of Obstetrics and Gynecology 2, Kawasaki Medical School, Okayama, Japan t-muratactac@gmail.com all@anticancer.com.
  • Hozumi C; AntiCancer Japan Inc, Narita, Japan.
  • Hiroshima Y; Department of Cancer Genome Medicine, Kanagawa Cancer Center Research Institute, Kanagawa, Japan.
  • Shimoya K; Department of Obstetrics and Gynecology 1, Kawasaki Medical School, Kurashiki, Japan.
  • Hongo A; Department of Obstetrics and Gynecology 2, Kawasaki Medical School, Okayama, Japan.
  • Inubushi S; Breast Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Tanino H; Breast Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Hoffman RM; AntiCancer Inc, San Diego, CA, U.S.A. t-muratactac@gmail.com all@anticancer.com.
In Vivo ; 34(6): 3241-3245, 2020.
Article en En | MEDLINE | ID: mdl-33144429
BACKGROUND/AIM: The discovery of the nude mouse model enabled the experimental growth of human-patient tumors. However, the low establishment rate of tumors in nude and other immunodeficient strains of mice has limited wide-spread clinical use. MATERIALS AND METHODS: In order to increase the establishment rate of surgical specimens of patient tumors, we transplanted tumors to nude mice subcutaneously along with large amounts of surrounding tissue of the tumor. RESULTS: The new transplantation method increased the establishment rate in nude mice to 66% compared to the old method of implanting the surgical tumor specimen with surrounding tissue removed (14%). High stage and presence of metastasis in the patient donor are positively correlated to tumor engraftment in nude mice. CONCLUSION: The new method can potentially allow most cancer patients who undergo surgery or biopsy to have their own mouse model for drug-sensitivity testing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Objetivos / Neoplasias Límite: Animals / Humans Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Objetivos / Neoplasias Límite: Animals / Humans Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article Pais de publicación: Grecia