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Thiol/Disulfide Homeostasis as an Early Biomarker to Differentiate Sepsis from Pneumonia in Intensive Care Units.
Cakir, Esra; Gok, Gamze; Erel, Ozcan; Turan, Isil Ozkocak.
Afiliación
  • Cakir E; Department of Anesthesiology and Clinical of Critical Care, Health Sciences University, Ankara Numune Education and Research Hospital, Ankara, Turkey.
  • Gok G; Department of Biochemistry, Ankara Yildirim Beyazit University, Ankara, Turkey.
  • Erel O; Department of Biochemistry, Ankara Yildirim Beyazit University, Ankara, Turkey.
  • Turan IO; Department of Anesthesiology and Clinical of Critical Care, Health Sciences University, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Comb Chem High Throughput Screen ; 24(9): 1446-1452, 2021.
Article en En | MEDLINE | ID: mdl-33135606
BACKGROUND: It is possible that patients with pneumonia may also have sepsis and the separation of these two clinical entities may cause some trouble to clinicians. OBJECTIVE: In order to separate a patient with pneumonia and a patient with sepsis, we qualify thiol/disulfide homeostasis as a potential biomarker. METHODS: This study was designed between February 2018 - February 2019 prospectively. All patients in the intensive care unit with pneumonia and sepsis were enrolled in the study. At the time of hospitalization, thiol/disulfide homeostasis was measured. Patients diagnosed with sepsis and pneumonia were compared, in regards to thiol/disulfide homeostasis. RESULTS: During research period, 103 patients with sepsis and 120 patients with pneumonia were enrolled into the study. When we compared native-thiol, total-thiol, and disulfide levels in both sepsis and pneumonia patients, we had similar results (p>0.05). In sepsis group, index-1 (disulfide/native thiol ratio) and index-2 (disulfide/total thiol ratio) were found to be statistically higher than the pneumonia group, and index-3 (native thiol/total thiol ratio) was statistically lower than the pneumonia group (p=0.020, p= 0.021, p=0.021, respectively). CONCLUSION: In this study, we showed that thiol/disulfide homeostasis could be used as new markers in the early period in order to separate patients with sepsis and patients with pneumonia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Compuestos de Sulfhidrilo / Sepsis / Disulfuros / Unidades de Cuidados Intensivos Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Comb Chem High Throughput Screen Asunto de la revista: BIOLOGIA MOLECULAR / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Emiratos Árabes Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Compuestos de Sulfhidrilo / Sepsis / Disulfuros / Unidades de Cuidados Intensivos Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Comb Chem High Throughput Screen Asunto de la revista: BIOLOGIA MOLECULAR / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Emiratos Árabes Unidos