Your browser doesn't support javascript.
loading
Long-term outcomes after resection of alcohol-related versus hepatitis-related hepatocellular carcinoma: A SEER-Medicare database analysis.
Mehta, Rittal; Tsilimigras, Diamantis I; Paredes, Anghela; Dillhoff, Mary; Cloyd, Jordan M; Ejaz, Aslam; Tsung, Allan; Spolverato, Gaya; Pawlik, Timothy M.
Afiliación
  • Mehta R; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Tang Qinghe; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Hepatobiliary and Pancreatic Surgery, Shanghai East Hospital, Tongji University, Shanghai, China.
  • Tsilimigras DI; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Paredes A; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Dillhoff M; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Cloyd JM; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Ejaz A; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Tsung A; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Spolverato G; Department of Surgical, Gastroenterological and Oncological Sciences, University of Padova, Italy.
  • Pawlik TM; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: tim.pawlik@osumc.edu.
Am J Surg ; 222(1): 167-172, 2021 07.
Article en En | MEDLINE | ID: mdl-33131693
BACKGROUND: The objective of this study was to define the relative impact of alcohol and/or hepatitis-related HCC etiology on the outcomes of patients who underwent resection or transplantation for HCC. METHODS: The SEER-Medicare database was used to identify patients with HCC between 2004 and 2015. Patients with history of alcohol abuse or hepatitis were identified. Overall survival (OS) and cancer-specific survival (CSS) were calculated using the Kaplan-Meier method and multivariable Cox regression analysis. RESULTS: Among 1140 patients, 11.9% (n = 136) of patients had alcohol-related HCC, 30.0% (n = 342) hepatitis-related HCC, and 58.1% (n = 662) had other cause-related HCC. On multivariable analysis, patients with alcohol-related HCC (HR:1.06, 95%CI:0.82-1.35) or hepatitis-related HCC (HR:1.05, 95%CI:0.88-1.26) had similar hazards of death compared with patients who had non-alcohol/non-hepatitis-related HCC. Patients who had tumor size ≤5 cm had lower hazards of death (HR:0.81, 95%CI:0.68-0.97), while individuals who underwent liver resection (vs. transplantation) had almost a two-fold higher hazards of death (HR:1.99, 95%CI:1.47-2.69). CONCLUSION: Tumor specific factors (i.e. tumor size and stage) and operative approach (i.e. resection vs. transplantation) -rather than HCC etiology- dictated both OS and CSS.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Hepatitis B Crónica / Hepatectomía / Hepatopatías Alcohólicas / Neoplasias Hepáticas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Am J Surg Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Hepatitis B Crónica / Hepatectomía / Hepatopatías Alcohólicas / Neoplasias Hepáticas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Am J Surg Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos