Alleviation of brain injury by applying TGN-020 in the supraoptic nucleus via inhibiting vasopressin neurons in rats of focal ischemic stroke.

Cui, Dan; Jia, Shuwei; Li, Tong; Li, Dongyang; Wang, Xiaoran; Liu, Xiaoyu; Wang, Yu-Feng

Cui, Dan; Jia, Shuwei; Li, Tong; Li, Dongyang; Wang, Xiaoran; Liu, Xiaoyu; Wang, Yu-Feng.

Afiliación

Cui D; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Jia S; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Li T; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Li D; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang X; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Liu X; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang YF; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China. Electronic address: yufengwang@ems.hrbmu.edu.cn.

Life Sci ; 264: 118683, 2021 Jan 01.

Article en En | MEDLINE | ID: mdl-33127515

Asunto(s)

Lesiones Encefálicas/metabolismo; Accidente Cerebrovascular Isquémico/metabolismo; Neuronas/metabolismo; Niacinamida/análogos & derivados; Núcleo Supraóptico/metabolismo; Tiadiazoles/administración & dosificación; Vasopresinas/metabolismo; Animales; Lesiones Encefálicas/tratamiento farmacológico; Accidente Cerebrovascular Isquémico/tratamiento farmacológico; Masculino; Microinyecciones/métodos; Neuronas/efectos de los fármacos; Niacinamida/administración & dosificación; Ratas; Ratas Wistar; Núcleo Supraóptico/efectos de los fármacos; Vasopresinas/antagonistas & inhibidores

Palabras clave

Aquaporin 4; Chloral hydrate; Glial fibrillary acidic protein; Glycogen synthase kinase 3ß; Hoechst: bisbenzimide; Middle cerebral artery occlusion; Neuroendocrine system; TGN-020: N-(1,3,4-thiadiazolyl)nicotinamide; TTC: 2,3,5-triphenyltetrazolium chloride

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Núcleo Supraóptico / Tiadiazoles / Lesiones Encefálicas / Vasopresinas / Niacinamida / Accidente Cerebrovascular Isquémico / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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