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The Life Cycle of the Mu-Opioid Receptor.
Cuitavi, Javier; Hipólito, Lucía; Canals, Meritxell.
Afiliación
  • Cuitavi J; Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of València, Burjassot, Spain.
  • Hipólito L; Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of València, Burjassot, Spain.
  • Canals M; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, the Midlands, UK. Electronic address: m.canals@nottingham.ac.uk.
Trends Biochem Sci ; 46(4): 315-328, 2021 04.
Article en En | MEDLINE | ID: mdl-33127216
Opioid receptors (ORs) are undisputed targets for the treatment of pain. Unfortunately, targeting these receptors therapeutically poses significant challenges including addiction, dependence, tolerance, and the appearance of side effects, such as respiratory depression and constipation. Moreover, misuse of prescription and illicit narcotics has resulted in the current opioid crisis. The mu-opioid receptor (MOR) is the cellular mediator of the effects of most commonly used opioids, and is a prototypical G protein-coupled receptor (GPCR) where new pharmacological, signalling and cell biology concepts have been coined. This review summarises the knowledge of the life cycle of this therapeutic target, including its biogenesis, trafficking to and from the plasma membrane, and how the regulation of these processes impacts its function and is related to pathophysiological conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Opioides / Analgésicos Opioides Límite: Animals Idioma: En Revista: Trends Biochem Sci Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Opioides / Analgésicos Opioides Límite: Animals Idioma: En Revista: Trends Biochem Sci Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido